Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Institute for Metabolic Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai, China.
Adv Exp Med Biol. 2019;1193:135-154. doi: 10.1007/978-981-13-6260-6_8.
Obesity is multifactorial and complex. Remarkable progress has been made recently in search for polygenic obesity through genome-wide association study (GWAS), but biology of polygenic effects on obesity is largely poor. This review summarizes the available evidence and provides an overview of the links between ALDH2 variants and adiposity, which were firstly and mainly derived from studies of polygenic obesity and also indirectly investigated by using cell lines and mice. The genetic association studies have observed consistent associations of ALDH2 variants with obesity-related traits including BMI, waist circumference (WC), waist-to-hip ratio (WHR), and visceral fat accumulation. In consideration of ALDH2 variants with enzyme activity and alcohol consumption behavior in physiological mechanism studies, we proposed a model by which the physiological and behavioral consequences of alcohol consumption serve as an intermediary process between polymorphisms in ALDH2 and obesity.
肥胖是多因素和复杂的。通过全基因组关联研究（GWAS）寻找多基因肥胖，最近已经取得了显著进展，但多基因对肥胖的生物学影响在很大程度上仍不清楚。本综述总结了现有证据，并概述了 ALDH2 变异与肥胖之间的联系，这些联系最初主要是从多基因肥胖研究中得出的，也间接地通过细胞系和小鼠进行了研究。遗传关联研究观察到 ALDH2 变异与肥胖相关特征（包括 BMI、腰围（WC）、腰臀比（WHR）和内脏脂肪堆积）之间存在一致的关联。考虑到 ALDH2 变异与生理机制研究中的酶活性和饮酒行为有关，我们提出了一个模型，即饮酒的生理和行为后果在 ALDH2 多态性与肥胖之间起到了中介作用。
