睾丸原位癌：精液中的非整倍体细胞。
Carcinoma in situ of the testis: aneuploid cells in semen.
作者信息
Giwercman A, Clausen O P, Skakkebaek N E
机构信息
University Department of Obstetrics and Gynaecology, Rigshospitalet, Copenhagen, Denmark.
出版信息
Br Med J (Clin Res Ed). 1988 Jun 25;296(6639):1762-4. doi: 10.1136/bmj.296.6639.1762.
Abstract
The content of cellular DNA in ejaculates from eight patients with carcinoma in situ of the testis and 26 controls without evidence of testicular neoplasia was studied by flow cytometry. An aneuploid cell population with a ploidy value similar to that found for carcinoma in situ cells was detected in seminal fluid from four of the eight men with carcinoma in situ but in none of the controls. One year after orchidectomy or local irradiation in these four men no aneuploid cells were found in the semen. These findings show that a detectable proportion of malignant germ cells may be released into the seminal fluid of patients with carcinoma in situ of the testis. Analysis of seminal fluid may therefore aid in screening for early neoplasia of the testis.
摘要
采用流式细胞术研究了8例睾丸原位癌患者和26例无睾丸肿瘤证据的对照者精液中的细胞DNA含量。在8例原位癌男性患者中的4例精液中检测到一个非整倍体细胞群，其倍性值与原位癌细胞的相似，但在对照组中未检测到。这4名男性接受睾丸切除或局部放疗1年后，精液中未发现非整倍体细胞。这些发现表明，可检测到的一部分恶性生殖细胞可能释放到睾丸原位癌患者的精液中。因此，精液分析可能有助于睾丸早期肿瘤的筛查。
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