Skakkebaek N E
Histopathology. 1978 May;2(3):157-70. doi: 10.1111/j.1365-2559.1978.tb01706.x.
A light microscopical study on a total of 812 consecutive testicular biopsies from 555 infertile men revealed intratubular changes in germ cells compatible with a carcinoma in situ pattern in six oligospermic patients (I.I%); the changes were found in both testes in two of these men. Four of the six patients developed an invasive germ cell tumour within follow-up period of 1.3 to 4.5 years. The results confirm the malignant nature of these intratubular atypical germ cells. It is concluded that testicular biopsy may be useful for early detection and cure of germ cell carcinoma in patients at risk, i.e. patients with cryptorchidism, infertile men or patients with previous cancer of one testis.
对555名不育男性连续进行的812次睾丸活检进行的光镜研究显示，6名少精子症患者（1.1%）的生精细胞存在与原位癌模式相符的小管内变化；其中2名男性的双侧睾丸均发现了这些变化。6名患者中有4名在1.3至4.5年的随访期内发展为浸润性生殖细胞肿瘤。结果证实了这些小管内非典型生殖细胞的恶性性质。得出的结论是，睾丸活检可能有助于对有风险的患者，即隐睾症患者、不育男性或既往有一侧睾丸癌的患者早期发现和治愈生殖细胞癌。
