Cátedra de Química Analítica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina.
Facultad de Farmacia y Bioquímica, Departamento de Tecnología Farmacéutica, CONICET, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina.
Future Med Chem. 2019 Jul;11(14):1791-1810. doi: 10.4155/fmc-2018-0452. Epub 2019 Aug 1.
Dendrimers are synthetic polymers that grow in three dimensions into well-defined structures. Their morphological appearance resembles a number of trees connected by a common point. Dendritic nanoparticles have been studied for a large number of pharmaceutical and biomedical applications including gene and drug delivery, clinical diagnosis and MRI. Despite the application of dendrimers, research is still in its childhood in comparison with liposomes and other nanomaterials. They are now playing a key role in several therapeutic strategies, with dendrimer-based products in clinical trials. The aim of this review is to describe the state-of-the-art of biomedical applications of dendrimers - and dendrimer conjugates - such as drug and gene delivery and antiviral activity.
树状聚合物是一种在三维空间中生长成具有明确结构的合成聚合物。它们的形态类似于许多通过共同的点连接的树。树突状纳米粒子已经在许多药物和生物医学应用中进行了研究，包括基因和药物传递、临床诊断和 MRI。尽管树突聚合物已经得到了应用，但与脂质体和其他纳米材料相比，其研究仍处于起步阶段。它们现在在几种治疗策略中发挥着关键作用，基于树突聚合物的产品正在临床试验中。本文的目的是描述树突聚合物及其缀合物在药物和基因传递以及抗病毒活性等生物医学应用方面的最新进展。
