Myung Ja Hye, Hsu Hao-Jui, Bugno Jason, Tam Kevin A, Hong Seungpyo
Departments of a Biopharmaceutical Sciences and b Bioengineering, University of Illinois, Chicago, IL, 60612, United States.
Departments of Biopharmaceutical Sciences and Bioengineering, University of Illinois, Chicago, IL, 60612, United States.
Curr Top Med Chem. 2017;17(13):1542-1554. doi: 10.2174/1568026616666161222104112.
Dendritic nanomaterials have attracted a great deal of scientific interest due to their high capacity for multifunctionalization and potential in various biomedical applications, such as drug/gene delivery and diagnostic systems. Depending on the molecular structure and starting monomers, several different types of dendrimers have been developed, including poly(amidoamine) (PAMAM), poly(propylenimine) (PPI), and poly(L-lysine) (PLL) dendrimers, in addition to modified dendritic nanomaterials, such as Janus dendrimers and dendritic block copolymers. The chemical structure and surface modification of dendritic nanomaterials have been found to play a critical role in governing their biological behaviors. In this review, we present a comprehensive overview focusing on the synthesis and chemical structures of dendrimers and modified dendritic nanomaterials that are currently being investigated for drug delivery, gene delivery, and diagnostic applications. In addition, the impact of chemical surface modification and functionalization to the dendritic nanomaterials on their therapeutic and diagnostic applications are highlighted.
树枝状纳米材料因其多功能化能力强以及在药物/基因递送和诊断系统等各种生物医学应用中的潜力而引起了广泛的科学关注。根据分子结构和起始单体的不同，已经开发出几种不同类型的树枝状聚合物，包括聚酰胺胺（PAMAM）、聚亚丙基亚胺（PPI）和聚L-赖氨酸（PLL）树枝状聚合物，此外还有修饰的树枝状纳米材料，如Janus树枝状聚合物和树枝状嵌段共聚物。人们发现树枝状纳米材料的化学结构和表面修饰在控制其生物学行为方面起着关键作用。在这篇综述中，我们全面概述了目前正在研究用于药物递送、基因递送和诊断应用的树枝状聚合物和修饰树枝状纳米材料的合成及化学结构。此外，还强调了树枝状纳米材料的化学表面修饰和功能化对其治疗和诊断应用的影响。
