Subjective effects from the first cigarette of the day vary with precigarette affect in premenopausal female daily smokers.

The 1st cigarette of the day is strongly tied to tobacco dependence. However, prior research has not investigated whether within-subject (WS) day-to-day fluctuations in prefirst-cigarette affect are associated with the subjective effects from the 1st cigarette of the day or whether these associations differ by smokers' average prefirst-cigarette affect. In the current study, 85 premenopausal female daily smokers completed baseline measures and 35 days of ecological momentary assessment. Prefirst-cigarette positive affect (PA) and negative affect (NA) were assessed prior to the 1st cigarette of the day and were partitioned into between-subjects (BS) and WS variables. Pleasurable and NA relief effects were assessed following the 1st cigarette of the day. On days when women reported higher than their usual prefirst-cigarette PA (WS-PA), they reported more pleasurable effects. On days when women reported higher than their usual prefirst-cigarette WS-NA, they reported greater pleasurable effects and NA relief effects. Women with higher average prefirst-cigarette NA relative to others (BS-NA), reported greater NA relief effects. Women with higher average prefirst-cigarette PA relative to others (BS-PA) reported greater pleasurable and NA relief effects from smoking. The association of within-subject affect (i.e., that day's level of NA or PA) with NA relief effects is attenuated in female smokers with higher average prefirst-cigarette NA (i.e., Prefirst-Cigarette WS Affect × Prefirst-Cigarette BS-NA interaction). Results suggest that prefirst-cigarette affect may impact the subjective effects from the 1st cigarette of the day and that the association between prefirst-cigarette affect and NA relief effects may be dampened in women with greater average precigarette NA. (PsycInfo Database Record (c) 2020 APA, all rights reserved).