Viktorovna Sevostyanova E, Alekseevich Nikolaev Y, Yakovlevich Polyakov V, Michailovich Mitrofanov I
Department of Medical and Environmental Studies, Federal Research Center for Basic and Translational Medicine, Timakova str.2, Novosibirsk, 630117, Russian Federation.
Curr Hypertens Rev. 2020;16(2):138-147. doi: 10.2174/1573402115666190801104227.
Comorbidity of hypertension and hepatobiliary pathology has negative medical and social consequences, including an increase in the indicators of hospital admissions, disability and mortality.
The aim was to study the occurrence of hypertension combined with hepatobiliary diseases depending on social status, gender and age in 2003-2017 and their influence on indicators of metabolic processes in patients with a therapeutic profile.
A cross-sectional study using the inpatients' medical record database of the clinic of Federal Research Centre for Basic and Translational Medicine (Novosibirsk, Russia), which collects demographics, diagnoses (using ICD-10 codes), procedures and examinations of all inpatients from 2003-2017 was conducted. The incidence of comorbidity of hypertension and hepatobiliary pathology depending on age, gender and social status, based on the analysis of 13496 medical records was examined. A comparative analysis of biochemical parameters characterizing the main types of metabolism (lipid, protein, carbohydrate and purine) was carried out in 3 groups of patients: with hypertension; with hepatobiliary pathology, and with a combined pathology.
During the years 2003-2005, there was the greatest frequency of this comorbidity in workers, in women, in the age group 60 years and older. In 2009-2017, the highest incidence was observed in the male administrative staff. In patients with this comorbidity, more pronounced changes in carbohydrate, protein, lipid and purine metabolism were found in comparison with groups of patients with isolated diseases.
The results highlight the need to improve the system of prevention and treatment of comorbidity taking into account sex, age, occupation and features of metabolism.
高血压与肝胆疾病合并存在会产生负面的医学和社会后果，包括住院指标、残疾率和死亡率上升。
旨在研究2003年至2017年期间，高血压合并肝胆疾病的发生率与社会地位、性别和年龄的关系，以及它们对具有治疗特征患者代谢过程指标的影响。
采用俄罗斯新西伯利亚联邦基础与转化医学研究中心诊所的住院患者病历数据库进行横断面研究，该数据库收集了2003年至2017年所有住院患者的人口统计学信息、诊断（使用ICD - 10编码）、手术和检查情况。基于对13496份病历的分析，研究高血压与肝胆疾病合并症的发生率与年龄、性别和社会地位的关系。对三组患者的生化参数进行比较分析，这三组患者分别为：患有高血压；患有肝胆疾病；患有合并症。
在2003年至2005年期间，这种合并症在工人、女性以及60岁及以上年龄组中出现的频率最高。在2009年至2017年期间，男性行政人员的发病率最高。与患有单一疾病的患者组相比，患有这种合并症的患者在碳水化合物、蛋白质、脂质和嘌呤代谢方面有更明显的变化。
研究结果强调，需要改进合并症的预防和治疗体系，同时考虑性别、年龄、职业和代谢特征。
