: The Canary in the Mine of Antifungal Drug Resistance.

has rapidly emerged as a fungal pathogen of worldwide importance. Its impact on global health is due in large part to the high frequency of multidrug resistance among clinical isolates. Although resistance to amphotericin B is an unusual feature of this organism, its notoriety should also serve as notice that other more commonly encountered fungal pathogens also show multidrug resistance. Here, we review the epidemiology and mechanisms of resistance and discuss why the emergence of provides justification for increased research into mechanisms of drug resistance and the development of novel antifungal drugs.