Rhenium-Catalyzed Phthalide Synthesis from Benzamides and Aldehydes via C-H Bond Activation.
作者信息
Jia Bing, Yang Yunhui, Jin Xiqing, Mao Guoliang, Wang Congyang
机构信息
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences , Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190 , China.
Provincial Key Laboratory of Oil & Gas Chemical Technology, College of Chemistry and Chemical Engineering , Northeast Petroleum University , Daqing 163318 , China.
出版信息
Org Lett. 2019 Aug 16;21(16):6259-6263. doi: 10.1021/acs.orglett.9b02142. Epub 2019 Aug 1.
The [4 + 1] annulation of benzamides and aldehydes for phthalide synthesis was achieved via rhenium-catalyzed C-H activation, which demonstrates an unprecedented reaction pattern distinct from those of other transition-metal catalyses. The reaction also features readily available starting materials, a wide scope for both electro-rich and electro-deficient substrates, and the elimination of homoannulation byproducts.
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