Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Medical University of Warsaw, Faculty of Pharmacy with the Laboratory Medicine Division , Warsaw , Poland.
Expert Opin Drug Deliv. 2019 Sep;16(9):953-967. doi: 10.1080/17425247.2019.1651716. Epub 2019 Aug 12.
: Arterial hypertension is a disease of civilization that requires long-term treatment. Recently, growing interest in natural and synthetic polymers as drug delivery vehicles in controlled release dosage forms for improving the efficacy of treatment has been observed. : This review introduces biodegradable synthetic polyesters as macromolecular carriers of antihypertensive drugs. Although various, synthetic and natural polymer-drug conjugates and/or polymeric carriers of anticancer drugs are currently under preclinical and clinical studies, there is no such data for antihypertensive drugs. Therefore, it seems appropriate to use such materials for the treatment of hypertension. : There are currently only a few studies describing the use of synthetic polyesters in the arterial hypertension therapy. In order to the fact that there is a high demand for new, effective antihypertensive dosage forms, further studies for such drug carriers are certainly expected. Synthetic polyester carriers could improve the drug bioavailability and its pharmacokinetic properties by altering the pharmaceutical dosage form. This property is particularly useful for drugs with proven pharmacological action, but with limited application due to their inappropriate pharmacological properties. The development of new polymeric materials and technologies affords the opportunity to produce novel synthetic polyester DDSs.
动脉高血压是一种需要长期治疗的文明病。最近，人们对天然和合成聚合物作为药物传递载体在控释剂型中提高治疗效果的兴趣日益增加。
本综述介绍了作为抗高血压药物的生物可降解合成聚酯。尽管目前正在进行各种合成和天然聚合物-药物缀合物和/或抗癌药物的聚合物载体的临床前和临床研究，但尚无抗高血压药物的此类数据。因此，将这些材料用于治疗高血压似乎是合适的。
目前只有少数研究描述了合成聚酯在动脉高血压治疗中的应用。鉴于对新的、有效的抗高血压剂型的需求很高，肯定需要对此类药物载体进行进一步研究。通过改变药物剂型，合成聚酯载体可以提高药物的生物利用度及其药代动力学特性。对于已经证明具有药理学作用但由于其药理学性质不当而应用受限的药物，这种特性尤其有用。新的聚合材料和技术的发展为新型合成聚酯 DDS 的生产提供了机会。
