递送治疗性肽和蛋白质的挑战：基于丝的解决方案。
Challenges in delivering therapeutic peptides and proteins: A silk-based solution.
作者信息
Wu Junqi, Sahoo Jugal Kishore, Li Yamin, Xu Qiaobing, Kaplan David L
机构信息
Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA.
Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA.
出版信息
J Control Release. 2022 May;345:176-189. doi: 10.1016/j.jconrel.2022.02.011. Epub 2022 Feb 11.
Abstract
Peptide- and protein-based therapeutics have drawn significant attention over the past few decades for the treatment of infectious diseases, genetic disorders, oncology, and many other clinical needs. Yet, protecting peptide- and protein-based drugs from degradation and denaturation during processing, storage and delivery remain significant challenges. In this review, we introduce the properties of peptide- and protein-based drugs and the challenges associated with their stability and delivery. Then, we discuss delivery strategies using synthetic polymers and their advantages and limitations. This is followed by a focus on silk protein-based materials for peptide/protein drug processing, storage, and delivery, as a path to overcome stability and delivery challenges with current systems.
摘要
在过去几十年中，基于肽和蛋白质的疗法在治疗传染病、遗传疾病、肿瘤学以及许多其他临床需求方面引起了广泛关注。然而，在加工、储存和递送过程中保护基于肽和蛋白质的药物不被降解和变性仍然是重大挑战。在本综述中，我们介绍了基于肽和蛋白质的药物的特性以及与其稳定性和递送相关的挑战。然后，我们讨论了使用合成聚合物的递送策略及其优缺点。接下来重点介绍用于肽/蛋白质药物加工、储存和递送的基于丝蛋白的材料，作为克服当前系统稳定性和递送挑战的途径。
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