Sane Rohit M, Jadhav Pradeep R, Subhedar Sanjana N
Department of Pharmacology, MGM Medical College, Navi-Mumbai, India.
Department of Pharmacology, MGM Medical College, Kamothe Sector-1, Navi-Mumbai, Maharashtra 410209, India.
J Basic Clin Physiol Pharmacol. 2019 Aug 1;30(5):jbcpp-2018-0119. doi: 10.1515/jbcpp-2018-0119.
Background Caffeinated coffee, a psycho-stimulant, is widely consumed throughout the globe. However, its chronic consumption has deleterious effects on human health. Meanwhile, decaffeinated coffee has low content of caffeine and thus can be an alternative to caffeinated coffee. Therefore, the study was undertaken to explore and compare the acute effects of decaffeinated and caffeinated coffee on reaction time, mood and skeletal muscle strength in healthy volunteers. Methods This was a prospective, interventional, comparative type of study. The study included 70 healthy adults divided into two groups (Caffeinated coffee group and Decaffeinated coffee group). The following parameters were assessed: reaction time was assessed by digital display multiple-choice apparatus, mood by Visual Analogue Scale (VAS) and Profile of Mood States revised version (POMS) and skeletal muscle strength by hand dynamometer. All parameters in both groups were assessed pre-intervention (baseline) and 30 min post-intervention. Results In both groups (decaffeinated and caffeinated coffee) post-intervention, there was a statistically significant (p < 0.05) improvement in the reaction time (VRT) and mood (VAS, POMS) from the baseline. However, both groups did not show any significant effects on the skeletal muscle strength. Upon comparing the two groups, we found that caffeinated coffee showed higher and significant improvement of mood than decaffeinated coffee. Conclusions Decaffeinated coffee exerts an acute significant stimulatory effect on the reaction time and mood. However, these effects in comparison to caffeinated coffee are low. Further randomized control clinical trials are thus needed to validate these interesting findings.
背景 含咖啡因的咖啡是一种精神兴奋剂，在全球范围内被广泛饮用。然而，长期饮用对人体健康有有害影响。同时，脱咖啡因咖啡的咖啡因含量较低，因此可以作为含咖啡因咖啡的替代品。因此，本研究旨在探索和比较脱咖啡因咖啡和含咖啡因咖啡对健康志愿者反应时间、情绪和骨骼肌力量的急性影响。
方法 这是一项前瞻性、干预性、比较性研究。该研究纳入了70名健康成年人，分为两组（含咖啡因咖啡组和脱咖啡因咖啡组）。评估以下参数：反应时间通过数字显示多项选择仪器进行评估，情绪通过视觉模拟量表（VAS）和修订版情绪状态剖面图（POMS）进行评估，骨骼肌力量通过握力计进行评估。两组的所有参数均在干预前（基线）和干预后30分钟进行评估。
结果 在两组（脱咖啡因咖啡组和含咖啡因咖啡组）干预后，反应时间（VRT）和情绪（VAS、POMS）与基线相比有统计学意义的显著改善（p < 0.05）。然而，两组对骨骼肌力量均未显示出任何显著影响。比较两组时，我们发现含咖啡因咖啡比脱咖啡因咖啡在情绪改善方面表现出更高且显著的效果。
结论 脱咖啡因咖啡对反应时间和情绪有急性显著的刺激作用。然而，与含咖啡因咖啡相比，这些作用较低。因此，需要进一步的随机对照临床试验来验证这些有趣的发现。
