螨变应原在变应性疾病中的多重作用。
The multiple roles of mite allergens in allergic diseases.
出版信息
Curr Opin Allergy Clin Immunol. 2019 Dec;19(6):623-631. doi: 10.1097/ACI.0000000000000573.
PURPOSE OF REVIEW
Mites are the most worldwide spread allergens and relevant causative of respiratory allergies. Life cycle, component allergens, biological activity and immunogenicity are discussed in depth.
RECENT FINDINGS
It is now known that mite allergens are able to stimulate the innate immune system through different receptors, for example, TLRs and PARs. The activation of the cells in the airway mucosa is followed by type 2 polarizing cytokine production in predisposed individuals. This complex network plays a pivotal role into the promotion of Th2 differentiation.
SUMMARY
This is a comprehensive review regarding all the mite allergens known so far, including their location within dust mites, composition, biological activities and binding receptors relevant to the fate of the immunological response.
目的综述
螨类是分布最广的过敏原，也是导致呼吸道过敏的主要原因。本文深入探讨了螨类的生活史、成分过敏原、生物活性和免疫原性。
最近的发现
现在已知螨类过敏原能够通过不同的受体（例如 TLR 和 PAR）刺激先天免疫系统。在易感个体中，气道黏膜细胞的激活会导致 2 型极化细胞因子的产生。这个复杂的网络在促进 Th2 分化中起着关键作用。
总结
这是一篇关于迄今为止已知的所有螨类过敏原的综合综述，包括它们在尘螨中的位置、组成、生物活性以及与免疫反应命运相关的结合受体。
Zotero 插件