Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Univ. Lille, CNRS, CHU LILLE, UMR9193-PsychiC-SCALab, Pôle de Psychiatrie, F-59000, Lille, France.
Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; FIDMAG Germanes Hospitalàries, Sant Boi de Llobregat, Barcelona, Spain; Mental Health Research Networking Center (CIBERSAM), Madrid, Spain; Karolinska Institutet, Centre for Psychiatric Research and Education, Department of Clinical Neuroscience, Stockholm, Sweden; King's College London, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
Neurosci Biobehav Rev. 2019 Oct;105:52-59. doi: 10.1016/j.neubiorev.2019.07.018. Epub 2019 Jul 29.
Borderline personality disorder (BPD) and post-traumatic stress disorder (PTSD) are common psychiatric disorders. The nature of the relationship between BPD and PTSD remains controversial, but it has been suggested that these disorders should brought closer because of their many similarities. We thus performed a quantitative meta-analysis of resting-state functional imaging to assess similarities in the brain activation across BPD and PTSD diagnostic groups. Overlap analyses revealed decreased activation in the left and right precuneus of both BPD and PTSD groups when compared to control subjects. BPD showed significant increased, but PTSD showed decreased activation, relative to control subjects, in the anterior cingulate/paracingulate gyri and in the left superior frontal gyrus. Complementary overlap analyses on a subgroup of studies with similar sex and age distribution partially confirmed the main results as the same pattern of functional activation in the anterior cingulate and in the left superior frontal gyrus were found. Our findings are in agreement with the hypothesis that BPD and PTSD share common neuropathological pathways.
边缘型人格障碍 (BPD) 和创伤后应激障碍 (PTSD) 是常见的精神障碍。BPD 和 PTSD 之间的关系性质仍存在争议，但有人认为，由于这些障碍有许多相似之处，应该将它们放在一起研究。因此，我们进行了一项静息态功能磁共振成像的定量荟萃分析，以评估 BPD 和 PTSD 诊断组之间大脑激活的相似性。重叠分析显示，与对照组相比，BPD 和 PTSD 组的左、右楔前叶的激活减少。与对照组相比，BPD 显示出前扣带回/旁扣带回回和左额上回的显著增加，但 PTSD 显示出减少的激活。对具有相似性别和年龄分布的亚组研究进行的补充重叠分析部分证实了主要结果，因为在前扣带回和左额上回中发现了相同的功能激活模式。我们的研究结果与 BPD 和 PTSD 具有共同的神经病理学途径的假设一致。
