Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Klinik Für Psychiatrie Und Psychotherapie, Campus Benjamin Franklin, Berlin, Germany.
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität Zu Berlin, and Berlin Institute of Health, Institute of Medical Psychology, Berlin, Germany.
Eur J Psychotraumatol. 2021 Sep 22;12(1):1959706. doi: 10.1080/20008198.2021.1959706. eCollection 2021.
Childhood trauma (CT) is associated with altered brain anatomy. These neuroanatomical changes might be more pronounced in individuals with a psychiatric disorder. Post-traumatic stress disorder (PTSD) and borderline personality disorder (BPD) are more prevalent in individuals with a history of CT.
In this study, we examined limbic and total brain volumes in healthy women with and without a history of CT and in females with PTSD or BPD and a history of CT to see whether neuroanatomical changes are a function of psychopathology or CT.
In total, 128 women ( = 70 healthy controls without CT, = 25 healthy controls with CT, = 14 individuals with PTSD, and = 19 individuals with BPD) were recruited. A T1-weighted anatomical MRI was acquired from all participants for Freesurfer-based assessment of total brain, hippocampus, and amygdala volumes. Severity of CT was assessed with a clinical interview and the Childhood Trauma Questionnaire. Group differences in hippocampal and amygdala volumes (adjusted for total brain volume) and total brain volume (adjusted for height) were characterized by analysis of covariance.
Volume of the total brain, hippocampus, and amygdala did not differ between the four groups > .05). CT severity correlated negatively with total brain volume across groups ( = -0.20; = .029).
CT was associated with reduced brain volume but PTSD or BPD was not. The association between CT and reduced brain volume as a global measure of brain integrity suggests a common origin for vulnerability to psychiatric disorders later in life.
儿童期创伤（CT）与大脑解剖结构的改变有关。这些神经解剖结构的变化在有精神障碍的个体中可能更为明显。创伤后应激障碍（PTSD）和边缘型人格障碍（BPD）在有 CT 病史的个体中更为普遍。
本研究旨在检查有和无 CT 病史的健康女性以及有 CT 病史的 PTSD 或 BPD 女性的边缘系统和全脑体积，以了解神经解剖结构的变化是与精神病理学还是 CT 有关。
共招募了 128 名女性（=70 名无 CT 的健康对照组，=25 名有 CT 的健康对照组，=14 名 PTSD 患者，=19 名 BPD 患者）。所有参与者均接受 T1 加权解剖 MRI 扫描，用于 Freesurfer 评估全脑、海马体和杏仁核体积。使用临床访谈和儿童期创伤问卷评估 CT 严重程度。采用协方差分析描述海马体和杏仁核体积（按全脑体积校正）和全脑体积（按身高校正）在各组间的差异。
四组间全脑、海马体和杏仁核体积无差异（>0.05）。CT 严重程度与各组间的全脑体积呈负相关（= -0.20；=0.029）。
CT 与脑体积减少有关，但 PTSD 或 BPD 则没有。CT 与脑体积减少作为脑完整性的整体测量指标之间的关联表明，个体易患精神障碍的易感性在以后的生活中具有共同的起源。
