Zhang Sirui, Lin Junyu, Cheng Yangfan, Hou Yanbin, Shang Huifang
Department of Neurology, West China Hospital, Rare Disease Center, Sichuan University, Chengdu, China.
Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, China.
Front Neurol. 2023 Mar 30;14:1124158. doi: 10.3389/fneur.2023.1124158. eCollection 2023.
Functional neuroimaging could provide abundant information of underling pathophysiological mechanisms of the clinical triad including motor, cognitive and psychiatric impairment in Huntington's Disease (HD).
We performed a voxel-based meta-analysis using anisotropic effect size-signed differential mapping (AES-SDM) method.
6 studies (78 symptomatic HD, 102 premanifest HD and 131 healthy controls) were included in total. Altered resting-state brain activity was primarily detected in the bilateral medial part of superior frontal gyrus, bilateral anterior cingulate/paracingulate gyrus, left insula, left striatum, right cortico-spinal projections area, right inferior temporal gyrus area, right thalamus, right cerebellum and right gyrus rectus area. Premanifest and symptomatic HD patients showed different alterative pattern in the subgroup analyses.
The robust and consistent abnormalities in the specific brain regions identified in the current study could help to understand the pathophysiology of HD and explore reliable neuroimaging biomarkers for monitoring disease progression, or even predicting the onset of premanifest HD patients.
功能神经影像学可为亨廷顿舞蹈症（HD）临床三联征（包括运动、认知和精神障碍）潜在的病理生理机制提供丰富信息。
我们使用各向异性效应大小符号差异映射（AES-SDM）方法进行了基于体素的荟萃分析。
总共纳入了6项研究（78名有症状的HD患者、102名症状前HD患者和131名健康对照）。静息态脑活动改变主要在双侧额上回内侧部分、双侧前扣带回/旁扣带回、左侧岛叶、左侧纹状体、右侧皮质脊髓投射区、右侧颞下回区域、右侧丘脑、右侧小脑和右侧直回区域被检测到。症状前和有症状的HD患者在亚组分析中表现出不同的改变模式。
本研究中在特定脑区发现的稳健且一致的异常有助于理解HD的病理生理学，并探索可靠的神经影像学生物标志物以监测疾病进展，甚至预测症状前HD患者的发病。
