Environmental and Computational Chemistry Group, School of Pharmaceutical Sciences, Zaragocilla Campus, University of Cartagena, Cartagena 130015, Colombia.
Institute of Fish Culture Research - CINPIC, Department of Aquaculture Sciences, Faculty of Veterinary Medicine and Animal Science, University of Cordoba, Monteria 230002, Colombia.
Comp Biochem Physiol C Toxicol Pharmacol. 2019 Nov;225:108577. doi: 10.1016/j.cbpc.2019.108577. Epub 2019 Jul 29.
Cadmium (Cd) is a heavy metal with known deleterious effects on animal reproduction, decreasing the rate of fertilization of organisms such as fish. Prochilodus magdalenae is a very important fish species in Colombia, widely used by riparian communities from many rivers. Unfortunately, its population has been declining, whereas Cd seems to be more frequently detected in environmental matrices at Colombian ecosystems. The aim of this work was to determine the toxic effects of cadmium chloride on fertilization, sperm quality and mortality at 0, 1, 6 and 7 days post-hatching (dph) in this vulnerable species. The results indicated that Cd altered the fertilization and sperm quality by decreasing total motility and rapid and medium motilities of swimming spermatozoa. Results showed Cd produced 16.4 and 46.5% sperm motility inhibition, at 2.5 and 25 ppm, respectively. The heavy metal also impaired sperm curvilinear and straight-line velocities in a concentration-response dose. Cadmium-induced a dose-dependent effect on the mortality of the exposed larvae that depends on its development stage, with greater effects after 6 and 7 dph, observed at concentrations as low as 0.025 ppm. The results showed that the exposure to environmentally relevant Cd concentrations causes physiological changes in the initial stages of development of P. magdalenae, likely increasing the risk of reducing the fertility rate of this valuable fish species.
镉（Cd）是一种重金属，已知对动物繁殖具有有害影响，降低了鱼类等生物的受精率。巨口脂鲤（Prochilodus magdalenae）是哥伦比亚非常重要的鱼类物种，被许多河流的河岸社区广泛使用。不幸的是，其种群数量一直在下降，而 Cd 似乎在哥伦比亚生态系统的环境基质中更频繁地被检测到。本工作旨在确定氯化镉对该脆弱物种受精、精子质量和孵化后 0、1、6 和 7 天死亡率的毒性影响。结果表明，Cd 通过降低总活力以及快速和中等活力游泳精子的活力，改变了受精和精子质量。结果表明，Cd 在 2.5 和 25 ppm 时分别抑制了 16.4%和 46.5%的精子活力。重金属还以浓度反应剂量的方式损害了精子曲线和直线速度。Cd 对暴露幼虫的死亡率产生了剂量依赖性影响，这取决于其发育阶段，在 6 和 7 天龄时的影响更大，在低至 0.025 ppm 的浓度下就观察到了这种影响。结果表明，暴露于环境相关浓度的 Cd 会导致 P. magdalenae 发育初期发生生理变化，可能会增加降低这种有价值鱼类物种的生育率的风险。
