Department of Gastroenterology, Infectiology and Rheumatology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany.
Department of Gastroenterology, Infectiology and Rheumatology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany.
Joint Bone Spine. 2020 Jan;87(1):69-73. doi: 10.1016/j.jbspin.2019.07.007. Epub 2019 Jul 29.
To evaluate the performance of the Ankylosing Spondylitis Disease Activity Score based on a validated quick quantitative C-reactive protein assay (ASDAS-qCRP) as compared to ASDAS based on a routine lab CRP assay (ASDAS-CRP) and ASDAS based on erythrocyte sedimentation rate (ASDAS-ESR).
Disease activity assessment was performed in 50 patients with axial spondyloarthritis (axSpA). Routine lab CRP was measured in the central lab while the quantitative quick-CRP assay and ESR measurements were performed locally. ASDAS-CRP, ASDAS-qCRP and ASDAS-ESR were subsequently calculated.
The mean (±SD) serum level of the routine lab CRP (6.2±8.3mg/l) was lower than of the quick-CRP (7.4±8.4mg/l) (P<0.05). Whereat, there was no significant difference in the mean values of ASDAS-CRP and ASDAS-qCRP in axSpA patients (2.70±0.94 and 2.74±0.96, respectively, P=0.069), while the ASDAS-ESR (2.85±1.0) was significantly higher than ASDAS-CRP (P=0.036) and numerically higher than ASDAS-qCRP (P=0.125). In 47 of the 50 cases of axSpA (94%), patients were assigned to the same disease activity category according to ASDAS-CRP and ASDAS-qCRP.
ASDAS-qCRP performed similarly well compared to ASDAS-CRP with the absolute agreement on the disease activity category according to the ASDAS of 94%. ASDAS-qCRP is, therefore, feasible for an immediate decision-making in clinical practice and trials aimed at treating to target.
评估基于经过验证的快速定量 C 反应蛋白测定法的强直性脊柱炎疾病活动评分（ASDAS-qCRP）与基于常规实验室 CRP 测定法的 ASDAS（ASDAS-CRP）和基于红细胞沉降率的 ASDAS（ASDAS-ESR）的表现。
对 50 例轴性脊柱关节炎（axSpA）患者进行疾病活动评估。常规实验室 CRP 在中心实验室进行测量，而定量快速 CRP 测定和 ESR 测量则在当地进行。随后计算 ASDAS-CRP、ASDAS-qCRP 和 ASDAS-ESR。
常规实验室 CRP（6.2±8.3mg/l）的平均（±SD）血清水平低于快速 CRP（7.4±8.4mg/l）（P<0.05）。然而，axSpA 患者的 ASDAS-CRP 和 ASDAS-qCRP 的平均值之间没有显著差异（分别为 2.70±0.94 和 2.74±0.96，P=0.069），而 ASDAS-ESR（2.85±1.0）则显著高于 ASDAS-CRP（P=0.036），且数值上高于 ASDAS-qCRP（P=0.125）。在 50 例 axSpA 病例中的 47 例（94%）中，根据 ASDAS-CRP 和 ASDAS-qCRP，患者被分配到相同的疾病活动类别。
ASDAS-qCRP 与 ASDAS-CRP 表现相似，根据 ASDAS，疾病活动类别的绝对一致性为 94%。因此，ASDAS-qCRP 可用于临床实践和旨在达到治疗目标的试验中的即时决策。
