Department of Clinical Biochemistry, Iranshahr University of Medical Sciences, Iranshahr 9916643535, Iran.
Student Research Committee, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran.
Medicina (Kaunas). 2019 Jul 31;55(8):425. doi: 10.3390/medicina55080425.
Previous studies have investigated the impact of the rs2241880 (Thr300Ala) polymorphism on individual susceptibility to cancer, but the conclusions are still controversial. To get a more precise evaluation of the correlation between rs2241880 polymorphism and cancer susceptibility, we performed a meta-analysis of the association of all eligible studies. Searches were performed in the Web of Science, PubMed, Scopus and Google Scholar databases up to November 2018. A total of 12 case-control studies from 9 articles comprising 2254 cases and 4974 controls were included. Statistical analysis was achieved by STATA 14.1 and Review Manager 5.3 software. The odds ratios (ORs) with 95% confidence intervals (95% CIs) under five genetic models were used to determine the strength of association among rs2241880 polymorphism and cancer susceptibility. The findings did not support an association between the rs2241880 variant in either the overall study population or the subgroups, based on cancer types and ethnicity in any of the genetic models. As far as we know, our study is the first meta-analysis of the association between rs2241880 polymorphism and cancer risk. In conclusion, the findings of this meta-analysis proposes that the rs2241880 polymorphism may not play a role in cancer development. Further well-designed studies are necessary to clarify the precise role of the rs2241880 polymorphism on cancer risk.
先前的研究已经调查了 rs2241880（Thr300Ala）多态性对个体癌症易感性的影响，但结论仍存在争议。为了更准确地评估 rs2241880 多态性与癌症易感性之间的相关性，我们对所有合格研究进行了荟萃分析。检索了 Web of Science、PubMed、Scopus 和 Google Scholar 数据库，检索时间截至 2018 年 11 月。共有 9 篇文献中的 12 项病例对照研究被纳入，包括 2254 例病例和 4974 例对照。统计分析采用 STATA 14.1 和 Review Manager 5.3 软件。使用五种遗传模型下的优势比（ORs）和 95%置信区间（95%CI）来确定 rs2241880 多态性与癌症易感性之间的关联强度。研究结果不支持 rs2241880 变体与癌症易感性之间存在关联，无论是在总体研究人群中，还是在任何遗传模型下的癌症类型和种族亚组中。据我们所知，这是首次对 rs2241880 多态性与癌症风险之间的关联进行荟萃分析。总之，本荟萃分析的结果表明 rs2241880 多态性可能不会在癌症发展中发挥作用。需要进一步设计良好的研究来阐明 rs2241880 多态性对癌症风险的确切作用。
