Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Biochemistry and Genetics, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Immun Inflamm Dis. 2024 Feb;12(2):e1182. doi: 10.1002/iid3.1182.
Chronic hepatitis B (CHB) virus is the most common risk factor for developing liver malignancy. Autophagy is an essential element in human cell maintenance. Several studies have demonstrated that autophagy plays a vital role in liver cancer at different stages. In this systematic review, we intend to investigate the role of polymorphism and mutations of autophagy-related genes (ATGs) in the pathogenesis and carcinogenesis of the hepatitis B virus (HBV).
The search was conducted in online databases (Web of Science, PubMed, and Scopus) using Viruses, Infections, Polymorphism, Autophagy, and ATG. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria.
The primary search results led to 422 studies. By screening and eligibility evaluation, only four studies were relevant. The most important polymorphisms in hepatocellular carcinoma were rs2241880 in ATG16L1, rs77859116, rs510432, and rs548234 in ATG5. Furthermore, some polymorphisms are associated with an increased risk of HBV infection including, rs2241880 in ATG16L1 and rs6568431 in ATG5.
The current study highlights the importance of rs2241880 in ATG16L1 and rs77859116, rs510432, and rs548234 in ATG5 for HBV-induced HCC. Additionally, some mutations in ATG16L1 and ATG5 were important in risk of HBV infection. The study highlights the gap of knowledge in the field of ATG polymorphisms in HBV infection and HBV-induced HCC.
慢性乙型肝炎（CHB）病毒是导致肝脏恶性肿瘤的最常见危险因素。自噬是人类细胞维持的重要组成部分。几项研究表明，自噬在肝癌的不同阶段都发挥着重要作用。在本系统综述中，我们旨在研究自噬相关基因（ATG）的多态性和突变在乙型肝炎病毒（HBV）发病机制和癌变中的作用。
使用 Viruses、Infections、Polymorphism、Autophagy 和 ATG 在在线数据库（Web of Science、PubMed 和 Scopus）中进行检索。研究基于系统评价和荟萃分析的首选报告项目标准进行。
最初的搜索结果导致了 422 项研究。通过筛选和资格评估，只有四项研究相关。在肝细胞癌中最重要的多态性是 ATG16L1 的 rs2241880、ATG5 的 rs77859116、rs510432 和 rs548234。此外，一些多态性与 HBV 感染的风险增加有关，包括 ATG16L1 的 rs2241880 和 ATG5 的 rs6568431。
本研究强调了 ATG16L1 的 rs2241880 和 ATG5 的 rs77859116、rs510432 和 rs548234 对 HBV 诱导的 HCC 的重要性。此外，ATG16L1 和 ATG5 中的一些突变在 HBV 感染和 HBV 诱导的 HCC 的风险中也很重要。该研究突出了 ATG 多态性在 HBV 感染和 HBV 诱导的 HCC 中的知识空白。
