Soriano F, Santamaría M, Ponte C, Castilla C, Fernández-Roblas R
Department of Clinical Microbiology, Fundación Jiménez Diaz, Madrid, Spain.
Eur J Clin Microbiol Infect Dis. 1988 Jun;7(3):410-2. doi: 10.1007/BF01962350.
The minimum dosage of antibiotics which reduced mortality in rats intraperitoneally inoculated with an Escherichia coli isolate was determined. Low mortality rates (0-10%) were obtained when antibiotics with minimal or no inoculum effect (cefoxitin, cefmetazole and gentamicin) were administered to yield serum levels 3 to 20 times the MIC, while antibiotics with a pronounced inoculum effect (cefotaxime and aztreonam) had to be administered to yield serum levels 200 to 1,000 times the MIC determined with a standard (low) inoculum. Thus, it seems that the inoculum effect observed in vitro with some antibiotics for Escherichia coli may have clinical significance.
测定了对经腹腔接种大肠杆菌分离株的大鼠具有降低死亡率作用的抗生素最低剂量。当给予具有最小或无接种物效应的抗生素（头孢西丁、头孢美唑和庆大霉素）以使血清水平达到最低抑菌浓度（MIC）的3至20倍时，死亡率较低（0 - 10%），而具有显著接种物效应的抗生素（头孢噻肟和氨曲南）必须给予以使血清水平达到用标准（低）接种物测定的MIC的200至1000倍。因此，对于大肠杆菌，一些抗生素在体外观察到的接种物效应可能具有临床意义。
