用成纤维细胞干扰素治疗一名慢性活动性肝炎患者。循环T淋巴细胞数量增加，玫瑰花结抑制因子消失。
Fibroblast interferon treatment of a patient with chronic active hepatitis. Increased number of circulating T lymphocytes and elimination of rosette-inhibitory factor.
作者信息
Dolen J G, Carter W A, Horoszewicz J S, Vladutiu A O, Leibowitz A I, Nolan J P
出版信息
Am J Med. 1979 Jul;67(1):127-31. doi: 10.1016/0002-9343(79)90088-3.
A 23 year old woman with chronic active hepatitis documented by liver biopsy demonstrated persistent hepatitis B surface antigen, hepatitis B virus specific DNA polymerase hepatitis B core antigen (HBcAg), for approximately one year. The number of circulating T lymphocytes that rosetted with sheep erythrocytes was decreased, and a rosette-inhibitory factor was present in her peripheral blood. Interferon treatment (1 X 10(6) U/day intramuscularly for 82 days) resulted in a decrease of HBsAg and disappearance of HBcAg, (HBeAg) and specific DNA polymerase. In addition, the number of T lymphocytes increased to normal, and the rosette-inhibitory factor disappeared from the circulation. These findings suggest that the effect of interferon in chronic active hepatitis is mediated in part through its action on the immune system.
一名经肝活检证实为慢性活动性肝炎的23岁女性，持续存在乙肝表面抗原、乙肝病毒特异性DNA聚合酶及乙肝核心抗原（HBcAg）约一年时间。与绵羊红细胞形成玫瑰花结的循环T淋巴细胞数量减少，其外周血中存在一种玫瑰花结抑制因子。干扰素治疗（每天1×10⁶单位肌肉注射，共82天）导致HBsAg减少，HBcAg、HBeAg及特异性DNA聚合酶消失。此外，T淋巴细胞数量增至正常，循环中的玫瑰花结抑制因子消失。这些发现提示，干扰素在慢性活动性肝炎中的作用部分是通过其对免疫系统的作用介导的。
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