Kanner R E, Renzetti A D, Klauber M R, Smith C B, Golden C A
Am J Med. 1979 Jul;67(1):44-50. doi: 10.1016/0002-9343(79)90072-x.
One hundred fifty subjects were enrolled in a long-term study of obstructive lung diseases; 84 of these were subjected to five or more spirometric studies over a period of two or more years. Stepdown regression analysis was performed to determine the association between many different variables and the annual rates of change in the forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1). The following associations were noted to be significant (p less than 0.03); more favorable rates of change of the FVC and FEV1 were associated with a higher alpha1-antitrypsin level and older age. Less favorable changes were associated with more years of cigarette smoking, more airway reactivity and more frequent lower respiratory tract illnesses.
150名受试者参与了一项阻塞性肺病的长期研究；其中84人在两年或更长时间内接受了五次或更多次肺活量测定研究。进行逐步回归分析以确定许多不同变量与用力肺活量（FVC）和1秒用力呼气量（FEV1）的年变化率之间的关联。发现以下关联具有显著性（p小于0.03）；FVC和FEV1更有利的变化率与较高的α1-抗胰蛋白酶水平和较高年龄相关。较不利的变化与吸烟年限更长、气道反应性更高以及下呼吸道疾病更频繁相关。
