Silverman Edwin K
Channing Laboratory and Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Proc Am Thorac Soc. 2007 Dec;4(8):586-90. doi: 10.1513/pats.200706-068TH.
The impact of chronic obstructive pulmonary disease (COPD) exacerbations on decline in FEV(1) has been a controversial topic for decades. We will review some of the key studies in this area and discuss potential contributors to inconsistent results of these studies. Dissecting the heterogeneous COPD syndrome into meaningful subtypes and assessing the genetic and environmental influences on COPD-related phenotypes such as exacerbation frequency could clarify the impact of exacerbations on the natural history of COPD.
数十年来，慢性阻塞性肺疾病（COPD）急性加重对第一秒用力呼气容积（FEV₁）下降的影响一直是一个有争议的话题。我们将回顾该领域的一些关键研究，并讨论这些研究结果不一致的潜在原因。将异质性的COPD综合征分解为有意义的亚型，并评估遗传和环境对COPD相关表型（如急性加重频率）的影响，可能会阐明急性加重对COPD自然病程的影响。
