Division of Pulmonology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang-si, Gyeonggi-do, Republic of Korea.
Research Institute, National Health Insurance Service Ilsan Hospital, Goyang-si, Gyeonggi-do, Republic of Korea.
BMC Pulm Med. 2019 Aug 1;19(1):140. doi: 10.1186/s12890-019-0901-z.
Epidemiologic characteristics of nontuberculous mycobacterial (NTM) disease remain largely unknown. The objective of this study was to evaluate incidence, prevalence, and mortality of NTM infection in a large nationwide population-based cohort in Korea.
Data of the National Health Insurance Service database, an extensive health-related database including most Korean residents, were used. Adults with a primary diagnosis of NTM as determined by International Classification of Disease-Tenth Revision coding (A31) were identified between 2003 and 2016. Incidence, prevalence, and mortality of NTM infection were analyzed.
A total of 46,194 individuals had a primary diagnosis of NTM infection. Their mean age was 55.8 years. Of these subjects, 61.1% were females. Annual age-adjusted incidence and prevalence of NTM infection tended to increase rapidly from 2003 to 2016. Age-adjusted incidence and prevalence was 17.9 and 33.3 per 100,000 population in 2016. The incidence and prevalence were higher in females and the elderly. The 5-year mortality rate in the population with NTM infection was 17.8%. The standardized mortality ratio of patients with NTM infection to the general population was 2.16 (95% confidence interval: 2.10 to 2.22).
This large population-based study showed that the incidence and prevalence of NTM infection in Korea increased rapidly from 2003 to 2016. They were higher in women and the elderly. The mortality rate in the population with NTM infection was higher than that in the general population.
非结核分枝杆菌（NTM）病的流行病学特征在很大程度上尚不清楚。本研究的目的是评估韩国一个大型全国人群队列中 NTM 感染的发病率、患病率和死亡率。
使用国家健康保险服务数据库的数据，该数据库是一个包含大多数韩国居民的广泛健康相关数据库。2003 年至 2016 年间，根据国际疾病分类第十次修订版编码（A31）确定了有 NTM 原发性诊断的成年人。分析了 NTM 感染的发病率、患病率和死亡率。
共有 46194 人被诊断为 NTM 感染的主要疾病。他们的平均年龄为 55.8 岁。其中 61.1%为女性。2003 年至 2016 年，NTM 感染的年年龄调整发病率和患病率呈快速上升趋势。2016 年年龄调整发病率和患病率分别为每 10 万人 17.9 和 33.3。女性和老年人的发病率和患病率较高。NTM 感染人群的 5 年死亡率为 17.8%。NTM 感染患者的标准化死亡率与普通人群相比为 2.16（95%置信区间：2.10 至 2.22）。
这项大型基于人群的研究表明，韩国的 NTM 感染发病率和患病率从 2003 年到 2016 年迅速上升。它们在女性和老年人中更高。NTM 感染人群的死亡率高于普通人群。
