2015 - 2018年中国家禽中禽腺病毒感染的流行病学调查
Epidemiological investigation of fowl adenovirus infections in poultry in China during 2015-2018.
作者信息
Chen Li, Yin Lijuan, Zhou Qingfeng, Peng Peng, Du Yunping, Liu Linlin, Zhang Yun, Xue Chunyi, Cao Yongchang
机构信息
State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Wen's Foodstuffs Group Co., Ltd, Yunfu, Guangdong, China.
出版信息
BMC Vet Res. 2019 Aug 1;15(1):271. doi: 10.1186/s12917-019-1969-7.
BACKGROUND
Fowl adenoviruses (FAdVs) are associated with many diseases, resulting in huge economic losses to the poultry industry worldwide. Since 2015, outbreaks of FAdV infections with high mortality rates have been reported in China. A continued surveillance of FAdVs contributes to understand the epidemiology of the viruses.
RESULTS
We isolated 155 FAdV strains from diseased chickens from poultry in China between 2015 and 2018. PCR analysis determined that 123 samples were FAdV species C, 27 were FAdV species E, and five contained two different FAdV strains. The phylogenetic analysis demonstrates that these sequences of hexon regions were clustered into three distinct serotypes: FAdV-4 (79.4%, 123/155), FAdV-8a (13.5%, 21/155) and FAdV-8b (3.9%, 6/155), of which FAdV-4 was the dominant serotype in China.
CONCLUSIONS
The characterization of newly prevalent FAdV strains provides valuable information for the development of an effective control strategy for FAdV infections in chickens.
背景
禽腺病毒（FAdVs）与多种疾病相关，给全球家禽业造成巨大经济损失。自2015年以来，中国已报告了高死亡率的FAdV感染疫情。持续监测FAdVs有助于了解这些病毒的流行病学情况。
结果
2015年至2018年期间，我们从中国患病家禽的病鸡中分离出155株FAdV毒株。PCR分析确定，123个样本为FAdV C种，27个为FAdV E种，5个样本含有两种不同的FAdV毒株。系统发育分析表明，这些六邻体区域序列被聚类为三种不同的血清型：FAdV-4（79.4%，123/155）、FAdV-8a（13.5%，21/155）和FAdV-8b（3.9%，6/155），其中FAdV-4是中国的主要血清型。
结论
新流行的FAdV毒株的特征为制定有效的鸡FAdV感染控制策略提供了有价值的信息。
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