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在资源有限的情况下对霍乱传播动力学进行建模。

Modelling cholera transmission dynamics in the presence of limited resources.

作者信息

Nyabadza Farai, Aduamah Jennifer Mawunyo, Mushanyu Josiah

机构信息

Department of Pure and Applied Mathematics, University of Johannesburg, Auckland Park, 2006, South Africa.

African Institute for Mathematical Sciences, (AIMS), Mbour, Senegal.

出版信息

BMC Res Notes. 2019 Aug 1;12(1):475. doi: 10.1186/s13104-019-4504-9.

Abstract

OBJECTIVES

We study the transmission dynamics of cholera in the presence of limited resources, a common feature of the developing world. The model is used to gain insight into the impact of available resources of the health care system on the spread and control of the disease. A deterministic model that includes a nonlinear recovery rate is formulated and rigorously analyzed. Limited treatment is described by inclusion of a special treatment function. Center manifold theory is used to show that the model exhibits the phenomenon of backward bifurcation. Matlab has been used to carry out numerical simulations to support theoretical findings.

RESULTS

The model analysis shows that the disease free steady state is locally stable when the threshold [Formula: see text]. It is also shown that the model has multiple equilibria and the model exhibits the phenomenon of backward bifurcation whose implications to cholera infection are discussed. The results are useful for the public health planning in resource allocation for the control of cholera transmission.

摘要

目标

我们研究在资源有限(这是发展中世界的一个共同特征)情况下霍乱的传播动力学。该模型用于深入了解医疗保健系统的可用资源对疾病传播和控制的影响。我们制定并严格分析了一个包含非线性恢复率的确定性模型。通过纳入一个特殊的治疗函数来描述有限的治疗情况。利用中心流形理论表明该模型呈现后向分岔现象。已使用Matlab进行数值模拟以支持理论研究结果。

结果

模型分析表明,当阈值[公式:见正文]时,无病稳态是局部稳定的。还表明该模型具有多个平衡点,且呈现后向分岔现象,并对霍乱感染的影响进行了讨论。这些结果对于控制霍乱传播的资源分配中的公共卫生规划很有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d55d/6676578/317ad4de9694/13104_2019_4504_Fig1_HTML.jpg

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