Eye Clinic, Department of Surgery and Translational Medicine, University of Florence, Italy.
Eye Clinic, Department of Surgery and Translational Medicine, University of Florence, Italy.
J Cataract Refract Surg. 2019 Aug;45(8):1148-1155. doi: 10.1016/j.jcrs.2019.03.002.
To investigate the safety and efficacy of the intraoperative use of a triphasic polymeric gel as corneal coating during cataract surgery and its effect on postoperative ocular comfort.
Eye Clinic, University of Florence, Italy.
Longitudinal observational retrospective study.
Data on patients who received an application of a polysaccharide blend of hydroxypropyl methylcellulose, xanthan gum, and carrageenan (EyeDRO) on the corneal surface and data on patients who received a balanced salt solution during phacoemulsification surgery were analyzed. The central corneal thickness (CCT) and epithelial thickness were examined using anterior segment optical coherence tomography, and the corneal basal epithelial cell (BEC) and Langerhans cell densities by in vivo confocal microscopy. The ocular surface disease index (OSDI) score, tear breakup time (TBUT), and Schirmer test I values were evaluated.
The study comprised data on 28 patients in the coating gel group and 26 patients in the balanced salt solution group. In the coating gel group, the CCT and epithelial thickness values returned to the baseline value within 5 and 15 postoperative days, respectively; the BEC and Langerhans cell densities returned to baseline levels within 15 and 30 postoperative days. In the balanced salt solution group, the mean BEC and Langerhans cell densities were significantly different from the preoperative values at all follow-up assessments. The TBUT returned to the preoperative level at day 5 in the coating gel group. The OSDI scores returned to the preoperative values after 15 days in the coating gel group and 30 days in the balanced salt solution group.
The use of a tripolymeric gel as a corneal coating during cataract surgery played a protective role on the corneal surface and reduced postoperative discomfort symptoms.
研究在白内障手术中使用三相聚合凝胶作为角膜涂层的安全性和有效性及其对术后眼部舒适度的影响。
意大利佛罗伦萨大学眼科诊所。
纵向观察性回顾性研究。
分析了在角膜表面应用羟丙基甲基纤维素、黄原胶和卡拉胶多糖混合物（EyeDRO）和在超声乳化手术中接受平衡盐溶液的患者的数据。使用眼前节光学相干断层扫描检查中央角膜厚度（CCT）和上皮厚度，并通过活体共聚焦显微镜检查角膜基底上皮细胞（BEC）和朗格汉斯细胞密度。评估眼表疾病指数（OSDI）评分、泪膜破裂时间（TBUT）和 Schirmer 试验 I 值。
该研究包括涂层凝胶组的 28 名患者和平衡盐溶液组的 26 名患者的数据。在涂层凝胶组中，CCT 和上皮厚度值分别在术后 5 天和 15 天内恢复到基线值；BEC 和朗格汉斯细胞密度在术后 15 天和 30 天内恢复到基线水平。在平衡盐溶液组中，所有随访评估时的平均 BEC 和朗格汉斯细胞密度与术前值均有显著差异。在涂层凝胶组中，TBUT 在术后第 5 天恢复到术前水平。涂层凝胶组的 OSDI 评分在 15 天内恢复到术前值，平衡盐溶液组在 30 天内恢复到术前值。
在白内障手术中使用三相聚合物凝胶作为角膜涂层对角膜表面起到了保护作用，并减轻了术后不适症状。
