Mannhalter J W, Wolf H M, Pum M, Banekovich M, Hutterer J, Brandstätter R, Eibl M M
Institute of Immunology, University of Vienna, Austria.
Immunol Invest. 1988 Apr;17(2):147-57. doi: 10.3109/08820138809055726.
Immunological parameters previously shown to constitute an increased risk for progression towards AIDS have been observed in clinically asymptomatic individuals considered to be at risk for this syndrome. These parameters include severely decreased numbers of T helper cells (count below 400/mm3 blood for CD4+ cells were detected in 7 our of 33 HIV antibody-positive, asymptomatic homosexuals and in 3 out of 29 HIV antibody-positive, asymptomatic drug abusers) and elevated serum IgA and IgM levels (found in 7 to 30 percent of these subjects). Furthermore, up to 60% of risk group members showed a decreased lymphoproliferative response to tetanus toxoid as compared to only 11% of so-called low responders in the simultaneously tested healthy controls. Finally, the capacity to mount an immune response to viral glycoproteins was found to be impaired in individuals at risk for AIDS, as indicated by a low serum level of antibodies to tick-borne meningoencephalitis virus antigen in recently vaccinated subjects.
在被认为有患该综合征风险的临床无症状个体中，已观察到先前显示会增加向艾滋病进展风险的免疫参数。这些参数包括T辅助细胞数量严重减少（在33名HIV抗体阳性的无症状同性恋者中有7人、29名HIV抗体阳性的无症状药物滥用者中有3人检测到CD4 +细胞计数低于400/mm³血液）以及血清IgA和IgM水平升高（在这些受试者中有7%至30%出现）。此外，与同时检测的健康对照中仅11%的所谓低反应者相比，高达60%的风险组成员对破伤风类毒素的淋巴细胞增殖反应降低。最后，正如最近接种疫苗的受试者中针对蜱传脑膜脑炎病毒抗原的抗体血清水平较低所表明的那样，发现有患艾滋病风险的个体对病毒糖蛋白产生免疫反应的能力受损。
