口腔癌研究的全球概况
Global Scenario of Research in Oral Cancer.
作者信息
Sreekumar Vinod Nair
机构信息
Department of Oral and Maxillofacial Surgery, P.M.S College of Dental Sciences and Research, Kerala University of Health Sciences, Trivandrum, India.
出版信息
J Maxillofac Oral Surg. 2019 Sep;18(3):354-359. doi: 10.1007/s12663-018-1166-4. Epub 2018 Oct 16.
Abstract
INTRODUCTION
With 300,000 new cases diagnosed worldwide, oral cancer continues to be a major global public threat. In Indian subcontinent, oral cancer accounts for 30-40% of all cancer types.
METHODOLOGY
Early detection of oral cancer is still considered as the most effective way to improve survival. In this regard, early detection of oral premalignant lesions and conditions is quite important as it may help in prevention of oral cancer. Scientific evidence is available which clearly indicates that transition from normal epithelium to premalignancy to oral carcinoma is the result of accumulation of genetic and epigenetic alterations in a multi-step process.
CONCLUSION
Proper oral screening and understanding of the genetic and environmental factors involved in oral carcinogenesis will allow the emphasis of cancer medicine to shift from the therapy of established oral cancer to the prevention of oral carcinogenesis.
摘要
引言
全球每年有30万例新确诊的口腔癌病例，口腔癌仍然是一个重大的全球公共威胁。在印度次大陆，口腔癌占所有癌症类型的30%-40%。
方法
早期发现口腔癌仍然被认为是提高生存率的最有效方法。在这方面，早期发现口腔癌前病变和状况非常重要，因为这可能有助于预防口腔癌。现有科学证据清楚地表明，从正常上皮组织到癌前病变再到口腔癌的转变是多步骤过程中遗传和表观遗传改变积累的结果。
结论
适当的口腔筛查以及对口腔癌发生过程中涉及的遗传和环境因素的了解，将使癌症医学的重点从已确诊口腔癌的治疗转向口腔癌发生的预防。
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本文引用的文献
1
Influence of methylenetetrahydrofolate reductase polymorphisms in oral cancer patients.
J Oral Pathol Med. 2011 Jan;40(1):61-6. doi: 10.1111/j.1600-0714.2010.00943.x. Epub 2010 Oct 4.
2
LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications.
Mol Cancer. 2010 Mar 12;9:58. doi: 10.1186/1476-4598-9-58.
3
Cost-effectiveness of oral cancer screening: results from a cluster randomized controlled trial in India.
Bull World Health Organ. 2009 Mar;87(3):200-6. doi: 10.2471/blt.08.053231.
4
Tobacco chewing and female oral cavity cancer risk in Karunagappally cohort, India.
Br J Cancer. 2009 Mar 10;100(5):848-52. doi: 10.1038/sj.bjc.6604907.
5
Alterations of 3p21.31 tumor suppressor genes in head and neck squamous cell carcinoma: Correlation with progression and prognosis.
Int J Cancer. 2008 Dec 1;123(11):2594-604. doi: 10.1002/ijc.23834.
6
Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes.
Head Neck. 2008 Sep;30(9):1139-47. doi: 10.1002/hed.20867.
7
Discovery and verification of head-and-neck cancer biomarkers by differential protein expression analysis using iTRAQ labeling, multidimensional liquid chromatography, and tandem mass spectrometry.
Mol Cell Proteomics. 2008 Jun;7(6):1162-73. doi: 10.1074/mcp.M700500-MCP200. Epub 2008 Mar 13.
8
Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium.
J Neurosci. 2007 Aug 8;27(32):8546-57. doi: 10.1523/JNEUROSCI.1269-07.2007.
9
Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer.
Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4331-5. doi: 10.1158/1078-0432.CCR-06-2613.
10
Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator.
Carcinogenesis. 2007 Jul;28(7):1455-62. doi: 10.1093/carcin/bgm038. Epub 2007 Feb 16.
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