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Am J Trop Med Hyg. 2018 Sep;99(3_Suppl):4-9. doi: 10.4269/ajtmh.18-0032. Epub 2018 Jul 24.
3
Manuka honey and methylglyoxal increase the sensitivity of Staphylococcus aureus to linezolid.麦卢卡蜂蜜和甲基乙二醛可增加金黄色葡萄球菌对利奈唑胺的敏感性。
Lett Appl Microbiol. 2018 Jun;66(6):491-495. doi: 10.1111/lam.12880. Epub 2018 Apr 19.
4
The Gathering Storm: Is Untreatable Typhoid Fever on the Way?《酝酿中的风暴：无法治愈的伤寒即将出现？》
mBio. 2018 Mar 20;9(2):e00482-18. doi: 10.1128/mBio.00482-18.
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Emergence of an Extensively Drug-Resistant Serovar Typhi Clone Harboring a Promiscuous Plasmid Encoding Resistance to Fluoroquinolones and Third-Generation Cephalosporins.广泛耐药血清型 Typhi 菌株的出现，该菌株携带可编码对氟喹诺酮类和第三代头孢菌素耐药性的混杂质粒。
mBio. 2018 Feb 20;9(1):e00105-18. doi: 10.1128/mBio.00105-18.
6
Antibacterial Properties of Nonwoven Wound Dressings Coated with Manuka Honey or Methylglyoxal.涂有麦卢卡蜂蜜或甲基乙二醛的非织造伤口敷料的抗菌性能
Materials (Basel). 2017 Aug 16;10(8):954. doi: 10.3390/ma10080954.
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Gram-Negative Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group.革兰氏阴性菌感染：抗菌药物耐药性领导小组的研究重点、成果及未来方向
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Novel assay of antibacterial components in manuka honey using lucigenin-chemiluminescence-HPLC.采用鲁米诺化学发光-HPLC 法检测麦卢卡蜂蜜中的抗菌成分。
Anal Chim Acta. 2017 Feb 15;954:151-158. doi: 10.1016/j.aca.2016.12.004. Epub 2016 Dec 21.
9
The Antibacterial Activity of Australian Leptospermum Honey Correlates with Methylglyoxal Levels.澳大利亚茶树蜂蜜的抗菌活性与甲基乙二醛水平相关。
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Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments.甲基乙二醛诱导的衰老和疾病中的二羰基应激：基于甘油醛 1 的治疗的第一步。
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甲基乙二醛：对伤寒沙门氏菌及其他革兰氏阴性杆菌的血培养分离株的抗菌活性。

Methylglyoxal: Antimicrobial activity against blood culture isolates of Salmonella Typhi and other Gram negative rods.

作者信息

Afzal Raja Kamran, Khalid Fizza, Hannan Abdul, Ahmed Syed Azhar

机构信息

Dr. Raja Kamran Afzal, FCPS, PhD. Department of Pathology, Armed Forces Institute of Cardiology, Rawalpindi, Pakistan.

Fizza Khalid, Department of Pathology, University of Health Sciences, Lahore, Pakistan.

出版信息

Pak J Med Sci. 2019 Jul-Aug;35(4):1110-1114. doi: 10.12669/pjms.35.4.807.

DOI:10.12669/pjms.35.4.807
PMID:31372152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6659080/
Abstract

OBJECTIVES

To evaluate the activity of Methylglyoxal against the blood culture isolates of Salmonella Typhi and various Gram negative rods and to compare the activity of Methylglyoxal against S. Typhi and other Gram negative rods.

METHODS

It was an experimental study conducted at the Department of Microbiology, University of Health Sciences (UHS), Lahore-Pakistan in collaboration with the Department of Microbiology, CMH Lahore, from July 2011 to June 2012. Recent blood culture isolates of and other Gram negative rods were collected from different hospitals of Lahore and kept stored at -80°C. As per the latest CLSI guidelines, morphological, biochemical and serological identification was carried out and antimicrobial susceptibility was tested. A multi-point inoculator was used to carry out agar dilution for determination of MICs of MGO. Results were determined after compilation of data using latest SPSS version.

RESULTS

MIC of MGO against the clinical isolates of S. Typhi was 0.20 (2.8 ) and against Gram negative rods it was 0.21 (3.0 ). The p-value of MICs of MGO against the isolates of S. Typhi was 0.023 when compared with Gram negative rods (p<0.05; statistically significant).

CONCLUSION

MGO has a scientifically proven antimicrobial activity against blood culture isolates of S. Typhi and various Gram negative rods.

摘要

目的

评估甲基乙二醛对伤寒沙门菌血培养分离株及各种革兰氏阴性杆菌的活性，并比较甲基乙二醛对伤寒沙门菌和其他革兰氏阴性杆菌的活性。

方法

这是一项于2011年7月至2012年6月在巴基斯坦拉合尔健康科学大学（UHS）微生物学系与拉合尔CMH微生物学系合作开展的实验研究。从拉合尔不同医院收集近期的伤寒沙门菌及其他革兰氏阴性杆菌血培养分离株，并保存在-80°C。按照最新的CLSI指南，进行形态学、生化和血清学鉴定，并检测抗菌药敏性。使用多点接种仪进行琼脂稀释法测定甲基乙二醛的最低抑菌浓度（MIC）。使用最新版SPSS软件汇总数据后得出结果。

结果

甲基乙二醛对伤寒沙门菌临床分离株的MIC为0.20 （2.8 ），对革兰氏阴性杆菌的MIC为0.21 （3.0 ）。与革兰氏阴性杆菌相比，甲基乙二醛对伤寒沙门菌分离株的MIC的p值为0.023（p<0.05；具有统计学意义）。

结论

甲基乙二醛对伤寒沙门菌血培养分离株及各种革兰氏阴性杆菌具有经科学验证的抗菌活性。