Alawad Zainab M, Al-Omary Hanan L
Zainab M. Alawad, MSc. Assistant Lecturer, Department of Physiology, College of Medicine, University of Baghdad, Iraq.
Hanan L. Al-Omary, PhD. Assistant Professor, Department of Physiology, College of Medicine, University of Baghdad, Iraq.
Pak J Med Sci. 2019 Jul-Aug;35(4):1122-1127. doi: 10.12669/pjms.35.4.558.
To explore the correlation between maternal and cord blood prolactin, the correlation between cord prolactin and birth weight, and to compare cord blood prolactin in new-borns of women with normal pregnancy and women with pregnancy complications namely; gestational hypertension, gestational diabetes and preterm labour.
This study was performed from September to December 2018. Thirty-two women, delivered at Baghdad teaching hospital, and their newborns (32) were included. Maternal blood (5 ml) was taken before labour and cord blood (5 ml) was collected after placenta expulsion. Maternal and cord blood prolactin were analysed using fluorescence immunoassay.
Cord blood prolactin was higher in babies born to hypertensive women (405.28±77.52 ng/ml) than normal pregnancy women (244.80±60.80 ng/ml), P=0.000. Also, cord prolactin in gestational hypertension group was significantly higher than diabetic (P=0.006) and preterm labour (P=0.000) groups. No significant difference was noticed in cord blood prolactin in newborns of diabetic and normal pregnancy women (299.28±37.01, 244.80±60.80 ng/ml respectively, P=0.053). Preterm babies had lower cord prolactin (204.57±22.90 ng/ml) than normal pregnancy babies (244.80±60.80 ng/ml), however the difference was non-significant, P=0.118. Positive correlation was found between cord and maternal prolactin (P=0.000) and between cord prolactin and birth weight (P=0.018).
Cord blood prolactin is high in newborns of hypertensive women, low in preterm neonates. Diabetes has no effect on cord prolactin level.
探讨母血与脐血催乳素之间的相关性、脐血催乳素与出生体重之间的相关性，并比较正常妊娠妇女和患有妊娠并发症（即妊娠期高血压、妊娠期糖尿病和早产）的妇女所生新生儿的脐血催乳素水平。
本研究于2018年9月至12月进行。纳入了在巴格达教学医院分娩的32名妇女及其32名新生儿。分娩前采集母血（5毫升），胎盘娩出后采集脐血（5毫升）。采用荧光免疫分析法分析母血和脐血催乳素。
高血压妇女所生婴儿的脐血催乳素（405.28±77.52纳克/毫升）高于正常妊娠妇女所生婴儿（244.80±60.80纳克/毫升），P = 0.000。此外，妊娠期高血压组的脐血催乳素显著高于糖尿病组（P = 0.006）和早产组（P = 0.000）。糖尿病妇女和正常妊娠妇女所生新生儿的脐血催乳素无显著差异（分别为299.28±37.01、244.80±60.80纳克/毫升，P = 0.053）。早产婴儿的脐血催乳素（204.57±22.90纳克/毫升）低于正常妊娠婴儿（244.80±60.80纳克/毫升），但差异不显著，P = 0.118。脐血与母血催乳素之间（P = 0.000）以及脐血催乳素与出生体重之间（P = 0.018）存在正相关。
高血压妇女所生新生儿的脐血催乳素水平较高，早产新生儿的脐血催乳素水平较低。糖尿病对脐血催乳素水平无影响。
