Department of Paediatrics, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria.
Department of Paediatrics, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria.
PLoS One. 2019 Feb 7;14(2):e0211535. doi: 10.1371/journal.pone.0211535. eCollection 2019.
Lead toxicity is a cause of intellectual disability in children and majority of affected children live in developing countries. Its adverse effect on pregnancy outcome has also been documented.
To assess the relationship between maternal blood lead levels and umbilical cord blood lead levels in their corresponding newborn infants; to determine factors associated with high blood lead levels and the pregnancy outcome in participants.
This was a cross-sectional descriptive study carried out at a tertiary Teaching Hospital, Lagos, Nigeria. Four hundred and forty pregnant women and their respective newborns delivered at the study centre. Blood samples were obtained from the mothers and umbilical cord of the newborns at delivery and analysed by atomic absorption spectrophotometry. Socio-demographic and obstetric data was obtained by questionnaires administered to the mothers. The anthropometric measurements of the babies were taken at birth and clinical data recorded. Main outcome measures were blood lead levels in mother and baby pair, socio-demographic factors, birth weight, gestational age, length, occipito-frontal circumference.
The median maternal and umbilical blood lead level was 64.3μg/dl and 39.2μg/dl respectively. The levels were above 5μg/dl in 75.6% and 66.8% of mothers and umbilical cord respectively. There was a strong positive correlation between the maternal and umbilical cord blood lead levels (rs = 0.80). Use of calcium supplements during pregnancy was significantly associated with a lower maternal blood lead level (p = 0.010) while recent painting and renovation of residential accommodation were associated with a higher umbilical cord blood lead level (p = 0.025). There were no statistically significant associations between the maternal and umbilical cord blood lead levels and the gestational age and anthropometry of the newborns at birth.
The blood lead levels in newborns of women residing in Lagos, Nigeria are high and administration of antenatal calcium is associated with lower blood lead levels.
铅中毒是导致儿童智力残疾的一个原因，而大多数受影响的儿童生活在发展中国家。它对妊娠结局的不良影响也有记录。
评估母亲血液铅水平与新生儿脐带血铅水平之间的关系；确定与参与者血液铅水平升高相关的因素以及妊娠结局。
这是一项在尼日利亚拉各斯的一家三级教学医院进行的横断面描述性研究。在研究中心分娩的 440 名孕妇及其相应的新生儿。在分娩时从母亲和新生儿的脐带中抽取血液样本，并通过原子吸收分光光度法进行分析。通过问卷调查获得母亲的社会人口统计学和产科数据。对婴儿的人体测量学测量值在出生时进行，并记录临床数据。主要观察指标为母婴血液铅水平、社会人口统计学因素、出生体重、胎龄、身长、头围。
母亲和脐带血的中位血铅水平分别为 64.3μg/dl 和 39.2μg/dl。分别有 75.6%和 66.8%的母亲和脐带血的血铅水平超过 5μg/dl。母亲和脐带血的血铅水平之间存在很强的正相关（rs=0.80）。妊娠期间使用钙补充剂与母亲血铅水平较低显著相关（p=0.010），而最近住宅装修和翻修与脐带血铅水平较高相关（p=0.025）。母亲和脐带血的血铅水平与新生儿的胎龄和出生时的人体测量学指标之间没有统计学上的显著关联。
尼日利亚拉各斯妇女所生新生儿的血铅水平较高，产前补钙与血铅水平降低有关。
