Alhowikan Abdulrahman Mohammed, Al-Ayadhi Laila Yousef, Halepoto Dost Muhammad
Abdulrahman Mohammed Alhowikan, PhD. Department of Physiology, Faculty of Medicine, King Saud University, P O Box 2925, Riyadh 11461 and Saudi Arabia.
Laila Yousef AL-Ayadhi, MBBS, PhD. Autism Research and Treatment Center, Department of physiology, Faculty of Medicine, King Saud University, P O Box 2925, Riyadh 11461 and Saudi Arabia.
Pak J Med Sci. 2019 Jul-Aug;35(4):1179-1184. doi: 10.12669/pjms.35.4.269.
Autism spectrum disorder (ASD) is complex neurodevelopmental condition described by impairments in three main behavioral areas: social deficits, impaired communication, and repetitive behaviors. Despite many years of vast study, the causes of ASD are still unknown. Various risk factors including genetic, infectious, metabolic and immunological have been investigated however, environmental, nutritional and diabetes related risk factors have not received sufficient attention. This study has provided an insight into the comprehensive interaction between environmental pollution, dietary factors and diabetes mellitus that could lead to the advancement of this debilitating neurodevelopment disorder. The literature search was done using PubMed and Google Scholar databases up to October 2018. Key words "Environmental Pollution", "Nutritional Factors", "Diabetes Mellitus", "Autism Spectrum Disorder" were selected.
自闭症谱系障碍（ASD）是一种复杂的神经发育状况，其特征表现为三个主要行为领域存在障碍：社交缺陷、沟通障碍和重复行为。尽管经过多年广泛研究，但ASD的病因仍然不明。已经对包括遗传、感染、代谢和免疫等各种风险因素进行了调查，然而，环境、营养和糖尿病相关的风险因素尚未得到充分关注。本研究深入探讨了环境污染、饮食因素和糖尿病之间的综合相互作用，这些因素可能导致这种使人衰弱的神经发育障碍病情发展。文献检索使用了截至2018年10月的PubMed和谷歌学术数据库。选取了关键词“环境污染”“营养因素”“糖尿病”“自闭症谱系障碍”。
