自身免疫易感小鼠的巨噬细胞对白三烯C4的异常产生。
Aberrant production of leukotriene C4 by macrophages from autoimmune-prone mice.
作者信息
Santoro T J, Morris D H, Murphy R C, Baker R C
机构信息
Department of Medicine, University of Colorado Health Sciences Center, Denver.
出版信息
J Exp Med. 1988 Aug 1;168(2):783-8. doi: 10.1084/jem.168.2.783.
Abstract
Eicosanoids have been implicated in the pathogenesis of autoimmune diseases. In this study, peritoneal macrophages from autoimmune-prone mice were examined for their capacity to produce proinflammatory 5-lipoxygenase metabolites. The results indicate that enhanced production of leukotriene C4 is a common feature of murine autoimmunity and suggest further that aberrations in 5-lipoxygenase activity may play a role in the development of lupus.
摘要
类二十烷酸与自身免疫性疾病的发病机制有关。在本研究中，检测了自身免疫易感小鼠腹腔巨噬细胞产生促炎5-脂氧合酶代谢产物的能力。结果表明，白三烯C4的产生增加是小鼠自身免疫的一个共同特征，并进一步提示5-脂氧合酶活性异常可能在狼疮的发展中起作用。
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