妊娠抑郁症状自我管理的初步研究方案。
Protocol for Pilot Study on Self-Management of Depressive Symptoms in Pregnancy.
机构信息
Patricia A. Kinser, PhD, WHNP-BC, RN, FNAP, FAAN, is Associate Professor, Virginia Commonwealth University School of Nursing, Richmond. Sara Moyer, RN, is Research Assistant, Virginia Commonwealth University School of Nursing, Richmond. Suzanne Mazzeo, PhD, is Professor, Department of Psychology, Virginia Commonwealth University School of Nursing, Richmond. Timothy P. York, PhD, is Associate Professor, Virginia Commonwealth University School of Medicine, Richmond. Ananda Amstadter, PhD, is Associate Professor, Virginia Commonwealth University School of Medicine, Richmond. Leroy Thacker, PhD, is Associate Professor, Virginia Commonwealth University Department of Biostatistics, Richmond. Angela Starkweather, PhD, ACNP-BC, CNRN, RN, FAAN, is Professor, University of Connecticut College of Nursing, Storrs.
出版信息
Nurs Res. 2020 Jan/Feb;69(1):82-88. doi: 10.1097/NNR.0000000000000382.
BACKGROUND
Pregnant women with depressive symptoms face significant treatment challenges and are in great need of safe, effective, accessible, inexpensive, and nonpharmacological self-management therapies to enhance well-being, reduce the burden of symptoms both during their pregnancy and postpartum, and prevent chronic sequelae.
OBJECTIVES
In this article, we describe the protocol for our pilot study testing a self-management intervention entitled, "Mindful Moms," designed to foster women's ability to address current depressive symptoms and enhance resilience to prevent recurrence.
METHODS
We will conduct a longitudinal pilot trial of the 12-week intervention with pregnant women with depressive symptoms (n = 40); the primary aim is to determine the feasibility and acceptability of the intervention. The secondary aim is to examine preliminary effects of the intervention on maternal psychobehavioral outcomes in pregnancy and 6 weeks postpartum. The third aim will quantify genome-wide and gene-specific DNA methylation patterns associated with depressive symptoms during pregnancy and investigate whether intervention participation influences these patterns.
RESULTS
This study is currently ongoing.
DISCUSSION
Findings from this study will inform future research addressing the need for nonpharmacological self-management interventions for pregnant women with depressive symptoms.
背景
患有抑郁症状的孕妇面临着重大的治疗挑战，她们非常需要安全、有效、易于获得、价格低廉且非药物的自我管理疗法，以提高幸福感，减轻怀孕期间和产后的症状负担，并预防慢性后遗症。
目的
本文介绍了我们正在进行的一项试点研究的方案，该研究旨在测试一种名为“正念妈妈”的自我管理干预措施，以培养女性应对当前抑郁症状的能力，并增强其预防复发的适应能力。
方法
我们将对患有抑郁症状的孕妇（n=40）进行为期 12 周的干预纵向试点试验；主要目的是确定干预措施的可行性和可接受性。次要目的是在妊娠和产后 6 周时，检查干预措施对产妇心理行为结果的初步影响。第三个目的是量化与妊娠期间抑郁症状相关的全基因组和基因特异性 DNA 甲基化模式，并探讨干预参与是否会影响这些模式。
结果
这项研究正在进行中。
讨论
本研究的结果将为解决患有抑郁症状的孕妇对非药物自我管理干预措施的需求提供信息。
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