Kim Jun Young, Hwang Jong-Moon, Park Jin-Sung, Park Sungwon, Lee Byung Joo, Park Donghwi
Department of Dermatology.
Department of Rehabilitation Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital.
Medicine (Baltimore). 2019 Aug;98(31):e16694. doi: 10.1097/MD.0000000000016694.
Although most complications of herpes zoster (HZ) are associated with the spread of varicella-zoster virus from the initially involved sensory ganglion, motor nerve impairment, such as limb weakness, is a rare but severe complication that is difficult to treat.
A 73-year-old female presented with sudden left upper limb pain and weakness after HZ.
Brachial plexopathy following HZ (postherpetic brachial plexopathy).
Despite alleviation of the vesicles with antiviral treatments, the left upper limb weakness and neuropathic pain did not improve. After obtaining patient's consent, ultrasound-guided polydeoxyribonucleotide (PDRN) injection was performed around the left brachial plexus.
The patient showed marked improvement in left arm pain from numerical rating scale (NRS) 9 to 4, 1 day after PDRN injection. Subsequently, the pain improved to NRS 3, and motor weakness improved to Medical Research Council grade 2 to 4.
PDRN can be considered a viable substitute for corticosteroid injection in treatment of motor weakness and neuropathic pain after HZ.
虽然带状疱疹（HZ）的大多数并发症与水痘-带状疱疹病毒从最初受累的感觉神经节扩散有关，但运动神经损伤，如肢体无力，是一种罕见但严重的并发症，难以治疗。
一名73岁女性在患HZ后出现突发左上肢疼痛和无力。
HZ后臂丛神经病变（疱疹后臂丛神经病变）。
尽管抗病毒治疗使水疱消退，但左上肢无力和神经性疼痛并未改善。在获得患者同意后，在左臂丛神经周围进行了超声引导下的聚脱氧核糖核苷酸（PDRN）注射。
PDRN注射1天后，患者左臂疼痛从数字评定量表（NRS）9分显著改善至4分。随后，疼痛改善至NRS 3分，运动无力改善至医学研究委员会2至4级。
在治疗HZ后的运动无力和神经性疼痛方面，PDRN可被视为皮质类固醇注射的一种可行替代方法。
