Ryu Kyoungho, Ko Dongchan, Lim Goeun, Kim Eugene, Lee Sung Hyun
Department of Anesthesiology and Pain Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Orthopedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Pain Res Manag. 2018 Mar 25;2018:8286190. doi: 10.1155/2018/8286190. eCollection 2018.
Rotator cuff tendinopathy is a primary cause of shoulder pain and dysfunction. Several effective nonsurgical treatment methods have been described for chronic rotator cuff tendinopathy. Prolotherapy with polydeoxyribonucleotide (PDRN), which consists of active deoxyribonucleotide polymers that stimulate tissue repair, is a nonsurgical regenerative injection that may be a viable treatment option. The objective of this study was to assess the efficacy of PDRN in the treatment of chronic rotator cuff tendinopathy.
The records of patients with chronic rotator cuff tendinopathy (=131) were reviewed retrospectively, and the patients treated with PDRN prolotherapy (=32) were selected. We measured the main outcome of the shoulder pain and disability index score on a numerical rating scale of average shoulder pain.
Compared with baseline data, significant improvements in the shoulder pain and disability index and pain visual analog scale scores were demonstrated at one week after the end of treatment, and at one month and three months later.
PDRN prolotherapy may improve the conservative treatment of painful rotator cuff tendinopathy for a specific subset of patients.
肩袖肌腱病是肩部疼痛和功能障碍的主要原因。对于慢性肩袖肌腱病，已有多种有效的非手术治疗方法被描述。聚脱氧核糖核苷酸（PDRN）注射疗法，其由刺激组织修复的活性脱氧核糖核苷酸聚合物组成，是一种非手术再生注射疗法，可能是一种可行的治疗选择。本研究的目的是评估PDRN在治疗慢性肩袖肌腱病中的疗效。
回顾性分析慢性肩袖肌腱病患者（n = 131）的记录，并选择接受PDRN注射疗法治疗的患者（n = 32）。我们使用平均肩部疼痛数字评定量表测量肩部疼痛和功能障碍指数评分这一主要结局指标。
与基线数据相比，在治疗结束后1周、1个月和3个月时，肩部疼痛和功能障碍指数以及疼痛视觉模拟量表评分均有显著改善。
PDRN注射疗法可能改善特定亚组疼痛性肩袖肌腱病患者的保守治疗效果。
