Leonard Allison C, Petrie Laurenne E, Cox Georgina
College of Biological Sciences, Department of Molecular and Cellular Biology , University of Guelph , 50 Stone Rd E , Guelph , Ontario N1G 2W1 , Canada.
ACS Infect Dis. 2019 Oct 11;5(10):1668-1681. doi: 10.1021/acsinfecdis.9b00193. Epub 2019 Aug 15.
Bacterial adhesion to the skin and mucosa is often a fundamental and early step in host colonization, the establishment of bacterial infections, and pathology. This process is facilitated by adhesins on the surface of the bacterial cell that recognize host cell molecules. Interfering with bacterial host cell adhesion, so-called anti-adhesive therapeutics, offers promise for the development of novel approaches to control bacterial infections. In this review, we focus on the discovery of anti-adhesives targeting the high priority pathogen . This organism remains a major clinical burden, and nasal colonization is associated with poor clinical outcomes. We describe the molecular basis of nasal colonization and highlight potentially efficacious targets for the development of novel nasal decolonization strategies.
细菌对皮肤和黏膜的黏附通常是宿主定植、细菌感染的建立以及发病机制中的一个基本且早期的步骤。这一过程由细菌细胞表面识别宿主细胞分子的黏附素所推动。干扰细菌与宿主细胞的黏附，即所谓的抗黏附疗法，为开发控制细菌感染的新方法带来了希望。在本综述中，我们聚焦于针对高优先级病原体的抗黏附剂的发现。这种病原体仍然是一个主要的临床负担，并且鼻腔定植与不良临床结果相关。我们描述了鼻腔定植的分子基础，并强调了开发新型鼻腔去定植策略的潜在有效靶点。
