Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584 CT Utrecht, the Netherlands.
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584 CT Utrecht, the Netherlands; Oncode Institute, 3584 CT Utrecht, the Netherlands; The Princess Maxima Center for Pediatric Oncology, 3584 CS Utrecht, the Netherlands.
Cell Stem Cell. 2019 Aug 1;25(2):174-183. doi: 10.1016/j.stem.2019.07.002.
Classic studies on hematopoiesis indicate that blood cell numbers are maintained by rare, hard-wired, transplantable stem cells (SCs). Subsequent studies in other organs have implicitly assumed that all SC hierarchies follow the design of the hematopoietic system. Lineage tracing techniques have revolutionized the study of solid tissue SCs. It thus appears that key characteristics of the hematopoietic SC hierarchy (rarity of SCs, specific marker expression, quiescence, asymmetric division, and unidirectional differentiation) are not generalizable to other tissues. In light of these insights, we offer a revised, generalizable definition of SC function: the ability to replace lost tissue through cell division.
经典的造血研究表明，血细胞数量由罕见的、固定的、可移植的干细胞（SCs）维持。随后在其他器官中的研究含蓄地假设所有的 SC 层次结构都遵循造血系统的设计。谱系追踪技术彻底改变了对固体组织 SC 的研究。因此，造血干细胞层次结构的关键特征（SCs 的稀有性、特定标志物的表达、静止、不对称分裂和单向分化）似乎不能推广到其他组织。有鉴于此，我们提供了一个经过修订的、可推广的 SC 功能定义：通过细胞分裂替代丢失组织的能力。
