Sartorelli Vittorio, Ciuffoli Veronica
Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Genes Dev. 2025 Feb 3;39(3-4):186-208. doi: 10.1101/gad.352277.124.
Adult stem cells maintain homeostasis and enable regeneration of most tissues. Quiescence, proliferation, and differentiation of stem cells and their progenitors are tightly regulated processes governed by dynamic transcriptional, epigenetic, and metabolic programs. Previously thought to merely reflect a cell's energy state, metabolism is now recognized for its critical regulatory functions, controlling not only energy and biomass production but also the cell's transcriptome and epigenome. In this review, we explore how metabolic pathways, metabolites, and transcriptional and epigenetic regulators are functionally interlinked in adult and aging skeletal muscle stem cells.
成体干细胞维持体内平衡，并使大多数组织得以再生。干细胞及其祖细胞的静止、增殖和分化是由动态转录、表观遗传和代谢程序严格调控的过程。代谢作用以前被认为仅仅反映细胞的能量状态，现在人们认识到它具有关键的调节功能，不仅控制能量和生物质的产生，还控制细胞的转录组和表观基因组。在这篇综述中，我们探讨了代谢途径、代谢产物以及转录和表观遗传调节因子在成年和衰老骨骼肌干细胞中是如何在功能上相互联系的。
