与巴西圣卡塔琳娜州猫白血病相关的猫白血病病毒
Feline Leukaemia Virus Associated with Leukaemia in Cats in Santa Catarina, Brazil.
作者信息
Cristo T G, Biezus G, Noronha L F, Gaspar T, Dal Pont T P, Withoeft J A, Furlan L V, Costa L S, Traverso S D, Casagrande R A
机构信息
Laboratory of Animal Pathology, Agroveterinary Sciences Center, University of Santa Catarina State, Av. Luís de Camões 2090, Conta Dinheiro, Lages, Santa Catarina, Brazil; Postgraduate Programme in Animal Science, University of Santa Catarina State, Av. Luís de Camões 2090, Conta Dinheiro, Lages, Santa Catarina, Brazil.
Laboratory of Animal Pathology, Agroveterinary Sciences Center, University of Santa Catarina State, Av. Luís de Camões 2090, Conta Dinheiro, Lages, Santa Catarina, Brazil; Veterinary Medicine, University of Santa Catarina State, Av. Luís de Camões 2090, Conta Dinheiro, Lages, Santa Catarina, Brazil.
出版信息
J Comp Pathol. 2019 Jul;170:10-21. doi: 10.1016/j.jcpa.2019.05.002. Epub 2019 Jun 7.
Leukaemia is a haemopoietic neoplasm originating from myeloid or lymphoid precursors in the bone marrow and may be either acute or chronic. These tumours are rare, but occur more frequently in cats because of an association with the feline leukaemia virus (FeLV) and feline immunodeficiency virus (FIV). To the best of our knowledge, no studies conducted in Brazil to date have analysed the association between leukaemia and FeLV and FIV infection in cats. The aim of this study was to perform a histopathological analysis of feline leukaemia and evaluate the association between leukaemia and FeLV and FIV infection in cats. The study evaluated 37 cats with leukaemia diagnosed between 2009 and 2017. The animals underwent necropsy examination, histopathology and immunohistochemistry with anti-FeLV gp70 and anti-FIV p24 gag antibodies. Of the evaluated animals, 54% (20/37) were males and 43.2% (16/37) were females. With respect to the life stage of the animals, 24.3% (9/37) were junior, 32.4% (12/37) were prime, 18.9% (7/37) were mature and 10.8% (4/37) were senior, and five animals were of unknown age. Myeloid leukaemia occurred in 56.8% (21/37) of the cases and lymphocytic leukaemia occurred in 43.2% (16/37) of the cases. Acute leukaemia (73%, 27/37) was more common than chronic leukaemia (27%, 10/37). The positivity for FeLV (78.4%, 29/37) and FIV (16.2%, 6/37) indicated a high association between FeLV infection and tumour development in the study region.
白血病是一种起源于骨髓中髓系或淋巴系前体细胞的造血肿瘤，可分为急性或慢性。这些肿瘤较为罕见，但在猫中更为常见，因为与猫白血病病毒（FeLV）和猫免疫缺陷病毒（FIV）有关。据我们所知，迄今为止在巴西尚未开展任何研究来分析猫白血病与FeLV和FIV感染之间的关联。本研究的目的是对猫白血病进行组织病理学分析，并评估猫白血病与FeLV和FIV感染之间的关联。该研究评估了2009年至2017年间诊断出患有白血病的37只猫。这些动物接受了尸检、组织病理学检查以及使用抗FeLV gp70和抗FIV p24 gag抗体进行的免疫组织化学检查。在评估的动物中，54%（20/37）为雄性，43.2%（16/37）为雌性。关于动物的生命阶段，24.3%（9/37）为幼年，32.4%（12/37）为青壮年，18.9%（7/37）为成年，10.8%（4/37）为老年，还有五只动物年龄未知。髓细胞白血病发生在56.8%（21/37）的病例中，淋巴细胞白血病发生在43.2%（16/37）的病例中。急性白血病（73%，27/37）比慢性白血病（27%，10/37）更为常见。FeLV（78.4%，29/37）和FIV（16.2%，6/37）呈阳性表明在研究区域FeLV感染与肿瘤发生之间存在高度关联。
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