Cristo T G, Biezus G, Noronha L F, Pereira L H H S, Withoeft J A, Furlan L V, Costa L S, Traverso S D, Casagrande R A
Laboratory of Animal Pathology, Agroveterinary Sciences Center, Brazil; Postgraduate Program in Animal Science, Brazil.
Laboratory of Animal Pathology, Agroveterinary Sciences Center, Brazil; Student of Veterinary Medicine, University of Santa Catarina State, Av. Luís de Camões 2090, Conta Dinheiro, Lages, Santa Catarina, Brazil.
J Comp Pathol. 2019 Jan;166:20-28. doi: 10.1016/j.jcpa.2018.10.171. Epub 2018 Nov 29.
Lymphoma is the most important haemopoietic tumour in cats and has been associated with feline leukaemia virus (FeLV) infection. In Brazil, no studies have established a correlation between FeLV infection and lymphoma. The aim of this study was to characterize lymphomas arising in cats in Brazil anatomically and microscopically, and to correlate these data with FeLV infection as determined by immunohistochemistry for the FeLV gp70 antigen. Fifty-three cats with lymphoma were evaluated. The mean age of junior, prime, mature, senior and geriatric cats was 1.65 years, 4.34 years, 8 years, 12.14 years and 15.5 years, respectively. The anatomical types of lymphoma were multicentric (43.4%, 23/53), mediastinal (33.96%, 18/53), renal (11.32%, 6/53), hepatic (5.66%, 3/53), nodal (3.77%, 2/53) and alimentary (1.89 %, 1/53). The histological types were small noncleaved-cell (33.96%, 18/53), mixed diffuse (22.64%, 12/53), immunoblastic (15.11%, 8/53), lymphoblastic (11, 32%, 6/53), small lymphocytic (9.43%, 5/53), small cleaved-cell (3.77%, 2/53) and large cell lymphomas (3.77%, 2/3). Immunopositivity for FeLV was observed in 56.6% (30/53) of the samples. FeLV positivity was equally distributed between the genders, but predominated in junior and prime cats. The degree of association between lymphoma and FeLV infection in Brazil was higher than that found in other countries, demonstrating the need to prevent and control the factors associated with infection.
淋巴瘤是猫最重要的造血肿瘤，且与猫白血病病毒（FeLV）感染有关。在巴西，尚无研究证实FeLV感染与淋巴瘤之间存在关联。本研究旨在从解剖学和显微镜角度对巴西猫身上发生的淋巴瘤进行特征描述，并将这些数据与通过FeLV gp70抗原免疫组化测定的FeLV感染情况相关联。对53只患有淋巴瘤的猫进行了评估。幼年、青壮年、成熟、老年和高龄猫的平均年龄分别为1.65岁、4.34岁、8岁、12.14岁和15.5岁。淋巴瘤的解剖类型为多中心型（43.4%，23/53）、纵隔型（33.96%，18/53）、肾型（11.32%，6/53）、肝型（5.66%，3/53）、淋巴结型（3.77%，2/53）和消化道型（1.89%，1/53）。组织学类型为小无裂细胞型（33.96%，18/53）、混合弥漫型（22.64%，12/53）、免疫母细胞型（15.11%，8/53）、淋巴母细胞型（11.32%，6/53）、小淋巴细胞型（9.43%，5/53）、小裂细胞型（3.77%，2/53）和大细胞淋巴瘤型（3.77%，2/3）。56.6%（30/53）的样本中观察到FeLV免疫阳性。FeLV阳性在两性中分布均匀，但在幼年和青壮年猫中占主导。巴西淋巴瘤与FeLV感染之间的关联程度高于其他国家，这表明有必要预防和控制与感染相关的因素。
