Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.
Harvard Medical School, Boston, MA, 02115, USA.
Nat Commun. 2019 Aug 2;10(1):3497. doi: 10.1038/s41467-019-11353-z.
Human memory is thought to depend on a circuit of connected brain regions, but this hypothesis has not been directly tested. We derive a human memory circuit using 53 case reports of strokes causing amnesia and a map of the human connectome (n = 1000). This circuit is reproducible across discovery (n = 27) and replication (n = 26) cohorts and specific to lesions causing amnesia. Its hub is at the junction of the presubiculum and retrosplenial cortex. Connectivity with this single location defines a human brain circuit that incorporates > 95% of lesions causing amnesia. Lesion intersection with this circuit predicts memory scores in two independent datasets (N1 = 97, N2 = 176). This network aligns with neuroimaging correlates of episodic memory, abnormalities in Alzheimer's disease, and brain stimulation sites reported to enhance memory in humans.
人类记忆被认为依赖于相互连接的大脑区域的回路，但这一假设尚未得到直接验证。我们利用 53 例导致遗忘症的中风病例报告和人类连接组图（n=1000），得出了人类记忆回路。该回路在发现（n=27）和复制（n=26）队列中具有可重复性，并且与导致遗忘症的病变特异性相关。其中心位于前下小叶和后扣带回皮质的交界处。与该位置的连接性定义了一个包含>95%导致遗忘症病变的人类大脑回路。该回路与两个独立数据集的记忆评分存在病变交叉（N1=97，N2=176）。该网络与情景记忆的神经影像学相关物、阿尔茨海默病的异常以及据报道可增强人类记忆的大脑刺激部位相吻合。
