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B29：免疫球蛋白基因超家族的一个成员，仅在β谱系细胞上表达。

B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells.

作者信息

Hermanson G G, Eisenberg D, Kincade P W, Wall R

机构信息

Molecular Biology Institute, University of California, Los Angeles 90024.

出版信息

Proc Natl Acad Sci U S A. 1988 Sep;85(18):6890-4. doi: 10.1073/pnas.85.18.6890.

DOI:10.1073/pnas.85.18.6890
PMID:3137575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC282084/
Abstract

A number of the glycoproteins identified on the surfaces of cells of the immune response belong to the immunoglobulin superfamily. We have isolated and characterized cDNA clones and the complete genomic gene encoding a B-cell-specific member of the immunoglobulin superfamily called "B29." This isolate is expressed at all stages in B-cell development beginning with the earliest precursor B cells undergoing immunoglobulin heavy chain gene diversity region----joining region gene (DH----JH) rearrangements. The protein sequence predicted by the B29 coding region contains a leader sequence and a single extracellular immunoglobulin-like domain, followed by a hydrophobic transmembrane segment and a charged intracytoplasmic domain. The immunoglobulin-like domain contains cysteines and other conserved amino acids characteristic of light chain variable and joining regions, but overall the sequence is only distantly related to immunoglobulins. Each of these domains is encoded in separate exons in the B29 gene, in analogy to other members of the immunoglobulin superfamily. The conserved structural features of the immunoglobulin-like domain in the B29 gene product resemble those of other members of the immunoglobulin superfamily involved in cell recognition and adhesion.

摘要

在免疫应答细胞表面鉴定出的许多糖蛋白属于免疫球蛋白超家族。我们已经分离并鉴定了编码免疫球蛋白超家族中一个名为“B29”的B细胞特异性成员的cDNA克隆和完整的基因组基因。这种分离物在B细胞发育的所有阶段都有表达，从最早经历免疫球蛋白重链基因多样性区域----连接区域基因（DH----JH）重排的前体B细胞开始。B29编码区预测的蛋白质序列包含一个前导序列和一个单一的细胞外免疫球蛋白样结构域，随后是一个疏水跨膜片段和一个带电荷的胞质结构域。免疫球蛋白样结构域包含半胱氨酸和轻链可变区及连接区特有的其他保守氨基酸，但总体而言，该序列与免疫球蛋白的关系仅很遥远。这些结构域中的每一个在B29基因中都由单独的外显子编码，这与免疫球蛋白超家族的其他成员类似。B29基因产物中免疫球蛋白样结构域的保守结构特征类似于参与细胞识别和黏附的免疫球蛋白超家族的其他成员。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c0/282084/919128b75c4c/pnas00297-0323-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c0/282084/06ba18505686/pnas00297-0323-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c0/282084/66558a7b5049/pnas00297-0323-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c0/282084/e9dec74e86f1/pnas00297-0323-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c0/282084/919128b75c4c/pnas00297-0323-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c0/282084/06ba18505686/pnas00297-0323-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c0/282084/66558a7b5049/pnas00297-0323-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c0/282084/e9dec74e86f1/pnas00297-0323-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f4c0/282084/919128b75c4c/pnas00297-0323-d.jpg

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1
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Proc Natl Acad Sci U S A. 1981 Apr;78(4):2502-6. doi: 10.1073/pnas.78.4.2502.
2
Thymoma production of T cell growth factor (Interleukin 2).胸腺瘤产生T细胞生长因子（白细胞介素2）。
J Immunol. 1980 Dec;125(6):2555-8.
3
Characterization of multiple immunoglobulin mu-chains synthesized by two clones of a B cell lymphoma.一个B细胞淋巴瘤的两个克隆合成的多种免疫球蛋白μ链的特征分析。
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J Biol Chem. 2012 Jul 20;287(30):25454-65. doi: 10.1074/jbc.M112.365825. Epub 2012 Jun 5.
4
Modulation of eIF5A expression using SNS01 nanoparticles inhibits NF-κB activity and tumor growth in murine models of multiple myeloma.利用 SNS01 纳米颗粒调控 eIF5A 表达抑制多发性骨髓瘤小鼠模型中 NF-κB 活性和肿瘤生长。
Mol Ther. 2012 Jul;20(7):1305-14. doi: 10.1038/mt.2012.94. Epub 2012 May 15.
5
An RNA-independent linkage of noncoding transcription to long-range enhancer function.非编码转录与长距离增强子功能的 RNA 独立性连接。
Mol Cell Biol. 2012 May;32(10):2020-9. doi: 10.1128/MCB.06650-11. Epub 2012 Mar 19.
6
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7
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8
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5
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