Eves F F, Curran H V, Shine P, Lader M H
Department of Psychiatry, Institute of Psychiatry, London, UK.
Psychopharmacology (Berl). 1988;95(3):386-9. doi: 10.1007/BF00181953.
Pipequaline (PK 8165) is a putative mixed agonist/antagonist at benzodiazepine receptors. The effects of pipequaline and diazepam on memory were assessed in 12 normal volunteers. Diazepam 10 mg or placebo was added to two doses of pipequaline, 50 and 150 mg, or to placebo in a double-blind crossover design. Diazepam produced impairments of episodic memory. In contrast, the effects of pipequaline were minor. Addition diazepam to pipequaline increased drowsiness and general lethargy, with a less marked effect occurring for the higher dose of pipequaline alone. Pipequaline did not antagonise any of the effects of diazepam.
哌喹啉（PK 8165）被认为是苯二氮䓬受体的混合激动剂/拮抗剂。在12名正常志愿者中评估了哌喹啉和地西泮对记忆的影响。在双盲交叉设计中，将10毫克地西泮或安慰剂添加到50毫克和150毫克的两剂哌喹啉中，或添加到安慰剂中。地西泮会损害情景记忆。相比之下，哌喹啉的影响较小。将地西泮添加到哌喹啉中会增加嗜睡和全身倦怠，单独使用较高剂量的哌喹啉时效果不太明显。哌喹啉并未拮抗地西泮的任何作用。
