Department of Anthropology and Geography, Colorado State University, Fort Collins, CO 80523-1787, USA.
Department of Sociology, Colorado State University, Fort Collins, CO 80523-1784, USA.
Brain Behav Immun. 2019 Nov;82:84-92. doi: 10.1016/j.bbi.2019.07.035. Epub 2019 Jul 31.
Previous research has identified a link between experiencing life as meaningful and purposeful-what is referred to as "eudaimonia"-and reduced expression of a stress-induced gene profile known as the "conserved transcriptional response to adversity" (CTRA). In the current study, we examine whether similar links between eudaimonic well-being and CTRA reduction occur in a sample of 56 individuals with a particularly strong engagement with virtual worlds: avid online videogame players. Results consistently linked higher eudaimonic well-being, and more specifically the social well-being subdomain of eudaimonia, to lower levels of CTRA gene expression. That favorable psychobiological relationship between eudaimonia and CTRA appeared most strongly among individuals reporting high levels of positive psychosocial involvement with gaming. Findings are consistent with the hypothesis that committed social/recreational activity may help damp CTRA expression especially among persons who are already experiencing some kind of threshold of positive eudaimonic experience.
先前的研究已经确定了将生活视为有意义和有目的的体验（即“幸福”）与应激诱导基因谱表达减少之间的联系，这种基因谱被称为“逆境的保守转录反应”（CTRA）。在目前的研究中，我们研究了在 56 名与虚拟世界有特别强烈联系的个体样本中，是否也存在类似的幸福与 CTRA 减少之间的联系：热衷在线视频游戏的玩家。结果一致表明，更高的幸福和更具体的幸福的社交子领域与更低的 CTRA 基因表达水平相关。在报告与游戏有高度积极的社会心理参与的个体中，这种有利的心理生物学关系最为明显。研究结果与假设一致，即投入的社交/娱乐活动可能有助于抑制 CTRA 的表达，特别是对于那些已经经历某种幸福体验的人。
