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监督注射设施使用模式:加拿大温哥华的一项前瞻性队列研究。

Supervised Injection Facility Utilization Patterns: A Prospective Cohort Study in Vancouver, Canada.

机构信息

British Columbia Centre on Substance Use, Vancouver, British Columbia, Canada; Department of Medicine, University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, Canada.

Department of Family Medicine, University of Calgary, Calgary, Alberta, Canada.

出版信息

Am J Prev Med. 2019 Sep;57(3):330-337. doi: 10.1016/j.amepre.2019.04.024. Epub 2019 Aug 1.

Abstract

INTRODUCTION

Although the health and community benefits of supervised injection facilities are well documented, little is known about long-term patterns of utilization of this form of health service. The present study seeks to longitudinally characterize discontinuation of use of a supervised injection facility in Vancouver, Canada.

METHODS

Data were drawn from 2 community-recruited prospective cohorts of people who inject drugs between December 2005 and December 2016. In 2018, extended Cox regression for recurrent events was used to examine factors associated with time to cessation of supervised injection facility use during periods of active injection.

RESULTS

Of 1,336 people who inject drugs that were followed for a median of 50 months, 847 (63.4%) participants reported 1,663 6-month periods of supervised injection facility use cessation while actively injecting drugs (incidence density of 26.6 events per 100 person-years). An additional 2,282 (57.8%) of the total 3,945 6-month periods of supervised injection facility use cessation occurred during periods of injection cessation. In multivariable analyses, enrollment in methadone maintenance therapy (adjusted hazard ratio=1.41) and HIV seropositivity (adjusted hazard ratio=1.23) were positively associated with supervised injection facility use cessation during periods of active injection, whereas homelessness (adjusted hazard ratio=0.59), at least daily heroin injection (adjusted hazard ratio=0.70), binge injection (adjusted hazard ratio=0.68), public injection (adjusted hazard ratio=0.67), nonfatal overdose (adjusted hazard ratio=0.73), difficulty accessing addiction treatment (adjusted hazard ratio=0.69), and incarceration (adjusted hazard ratio=0.70) were inversely associated with this outcome (all p<0.05). The most commonly reported reasons for supervised injection facility use cessation were injection drug use cessation (42.3%) and a preference for injecting at home (30.7%).

CONCLUSIONS

These findings suggest that this supervised injection facility successfully retains people who inject drugs at elevated risk of drug-related harms and indicate that many supervised injection facility clients neither use this service nor inject drugs perpetually.

摘要

简介

尽管监督注射设施对健康和社区的益处已有充分记录,但人们对这种卫生服务形式的长期使用模式知之甚少。本研究旨在对加拿大温哥华监督注射设施使用的停止进行纵向描述。

方法

数据来自于 2005 年 12 月至 2016 年 12 月期间招募的两个社区前瞻性吸毒者队列。2018 年,采用复发性事件的扩展 Cox 回归分析,研究了与活跃期内停止使用监督注射设施相关的因素。

结果

在中位随访 50 个月期间,1336 名吸毒者中有 847 人(63.4%)报告了 1663 个 6 个月的监督注射设施使用停止期,同时正在使用药物(发生率密度为每 100 人年 26.6 例)。在总共 3945 个 6 个月的监督注射设施使用停止期中,还有 2282 个(57.8%)发生在注射停止期间。多变量分析显示,美沙酮维持治疗(调整后的危害比=1.41)和 HIV 阳性(调整后的危害比=1.23)与活跃期内监督注射设施使用停止相关,而无家可归(调整后的危害比=0.59)、至少每日海洛因注射(调整后的危害比=0.70)、狂欢式注射(调整后的危害比=0.68)、公共注射(调整后的危害比=0.67)、非致命性过量(调整后的危害比=0.73)、难以获得成瘾治疗(调整后的危害比=0.69)和监禁(调整后的危害比=0.70)与该结果呈负相关(均 P<0.05)。停止使用监督注射设施的最常见原因是停止使用注射药物(42.3%)和更喜欢在家中注射(30.7%)。

结论

这些发现表明,该监督注射设施成功地留住了处于较高药物相关危害风险的吸毒者,并表明许多监督注射设施的客户既不使用这种服务,也不长期使用药物。

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