European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
Biochimie. 2019 Nov;166:4-18. doi: 10.1016/j.biochi.2019.07.026. Epub 2019 Aug 1.
The distribution of all peptidase homologues across all phyla of organisms was analysed to determine within which kingdom each of the 271 families originated. No family was found to be ubiquitous and even peptidases thought to be essential for life, such as signal peptidase and methionyl aminopeptides are missing from some clades. There are 33 peptidase families common to archaea, bacteria and eukaryotes and are assumed to have originated in the last universal common ancestor (LUCA). These include peptidases with different catalytic types, exo- and endopeptidases, peptidases with different tertiary structures and peptidases from different families but with similar structures. This implies that the different catalytic types and structures pre-date LUCA. Other families have had their origins in the ancestors of viruses, archaea, bacteria, fungi, plants and animals, and a number of families have had their origins in the ancestors of particular phyla. The evolution of peptidases is compared to recent hypotheses about the evolution of organisms.
分析了所有生物门的所有肽酶同源物的分布，以确定 271 个家族中的每一个起源于哪个王国。没有发现普遍存在的家族，甚至一些肽酶，如信号肽酶和甲硫氨酰氨肽酶，也缺失于某些进化枝中。有 33 个肽酶家族存在于古菌、细菌和真核生物中，被认为起源于最后一个共同的祖先（LUCA）。这些家族包括具有不同催化类型的肽酶、外肽酶和内肽酶、具有不同三级结构的肽酶以及具有相似结构但来自不同家族的肽酶。这意味着不同的催化类型和结构早于 LUCA 出现。其他家族起源于病毒、古菌、细菌、真菌、植物和动物的祖先，许多家族起源于特定门的祖先。肽酶的进化与最近关于生物进化的假设进行了比较。
