Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk (Antwerp), Belgium.
Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Wilrijk (Antwerp), Belgium; Department of Neurology and Alzheimer Center, University of Groningen and University Medical Center Groningen (UMCG), Groningen, The Netherlands.
Neurosci Biobehav Rev. 2019 Oct;105:72-80. doi: 10.1016/j.neubiorev.2019.07.019. Epub 2019 Aug 1.
With aging, our sleeping pattern alters. Elderly often wake unrested because their sleep time and sleep efficacy is reduced. In Alzheimer's disease (AD) patients, these alterations are even more pronounced and may further aggravate cognitive decline. Therefore, sleep disturbances greatly impact self-care ability, caregiver exhaustion and institutionalization rate. Reestablishing an effective sleep-wake cycle in these patients still remains an unresolved challenge, partly because sleep physiology is quite complex and multiple neurotransmitter systems contribute to a single process. Gaining a better understanding of sleep physiology will be crucial for further research. Conjointly, animal models, along with a multidisciplinary approach, will be of great value to establish a common ground between AD and sleep disturbances and work towards a potential therapeutic application.
随着年龄的增长，我们的睡眠模式会发生改变。老年人常常醒来时感到疲惫，因为他们的睡眠时间和睡眠效率降低了。在阿尔茨海默病（AD）患者中，这些变化更为明显，可能进一步加重认知能力下降。因此，睡眠障碍会极大地影响自理能力、照顾者的疲劳程度和住院率。在这些患者中重新建立有效的睡眠-觉醒周期仍然是一个未解决的挑战，部分原因是睡眠生理学非常复杂，多种神经递质系统共同参与一个过程。更好地了解睡眠生理学对于进一步的研究至关重要。此外，动物模型以及多学科方法将非常有价值，可以在 AD 和睡眠障碍之间建立共同点，并为潜在的治疗应用做出努力。
